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Gsdmc4 gasdermin C4 [ Mus musculus (house mouse) ]

Gene ID: 74548, updated on 8-Feb-2024

Summary

Official Symbol
Gsdmc4provided by MGI
Official Full Name
gasdermin C4provided by MGI
Primary source
MGI:MGI:1921798
See related
Ensembl:ENSMUSG00000055748 AllianceGenome:MGI:1921798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GsdmC-2; 9030605I04Rik
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to act upstream of or within programmed cell death. Predicted to be located in cytoplasm. Is expressed in genitourinary system and gut. Orthologous to human GSDMC (gasdermin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 65.4), large intestine adult (RPKM 35.7) and 2 other tissues See more
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Genomic context

See Gsdmc4 in Genome Data Viewer
Location:
15 D1; 15 28.07 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63762989..63784168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63891140..63912319, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C3 Neighboring gene gasdermin C-like 2 Neighboring gene gasdermin C-like, pseudogene Neighboring gene CYFIP related Rac1 interactor B Neighboring gene STARR-seq mESC enhancer starr_38847 Neighboring gene predicted gene, 25628

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gasdermin-C4
Names
gasderminC-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028992.1NP_083268.1  gasdermin-C4

    See identical proteins and their annotated locations for NP_083268.1

    Status: VALIDATED

    Source sequence(s)
    AK018537, AK163061, BY460367
    Consensus CDS
    CCDS49617.1
    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Related
    ENSMUSP00000140269.2, ENSMUST00000188108.7
    Conserved Domains (2) summary
    pfam04598
    Location:4233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272441
    Gasdermin_C; Gasdermin PUB domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    63762989..63784168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521502.4XP_006521565.1  gasdermin-C4 isoform X1

    See identical proteins and their annotated locations for XP_006521565.1

    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Conserved Domains (2) summary
    pfam04598
    Location:4233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272441
    Gasdermin_C; Gasdermin PUB domain
  2. XM_011245757.3XP_011244059.1  gasdermin-C4 isoform X2

    Conserved Domains (2) summary
    pfam04598
    Location:4233
    Gasdermin; Gasdermin family
    pfam17708
    Location:265432
    Gasdermin_C; Gasdermin PUB domain
  3. XM_011245754.3XP_011244056.1  gasdermin-C4 isoform X1

    See identical proteins and their annotated locations for XP_011244056.1

    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Conserved Domains (2) summary
    pfam04598
    Location:4233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272441
    Gasdermin_C; Gasdermin PUB domain
  4. XM_011245755.4XP_011244057.1  gasdermin-C4 isoform X1

    See identical proteins and their annotated locations for XP_011244057.1

    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Conserved Domains (2) summary
    pfam04598
    Location:4233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272441
    Gasdermin_C; Gasdermin PUB domain
  5. XM_011245756.3XP_011244058.1  gasdermin-C4 isoform X1

    See identical proteins and their annotated locations for XP_011244058.1

    UniProtKB/Swiss-Prot
    E9QKJ0, Q3TR54, Q9D326
    UniProtKB/TrEMBL
    A0A679B0N4
    Conserved Domains (2) summary
    pfam04598
    Location:4233
    Gasdermin; Gasdermin family
    pfam17708
    Location:272441
    Gasdermin_C; Gasdermin PUB domain