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Hyal5 hyaluronoglucosaminidase 5 [ Mus musculus (house mouse) ]

Gene ID: 74468, updated on 3-Apr-2024

Summary

Official Symbol
Hyal5provided by MGI
Official Full Name
hyaluronoglucosaminidase 5provided by MGI
Primary source
MGI:MGI:1921718
See related
Ensembl:ENSMUSG00000029678 AllianceGenome:MGI:1921718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933439A12Rik
Summary
Enables hyalurononglucosaminidase activity. Acts upstream of or within penetration of zona pellucida. Located in acrosomal vesicle and external side of plasma membrane. Orthologous to human SPAM1 (sperm adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 24.7) See more
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Genomic context

Location:
6 A3.1; 6 11.28 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (24857982..24891963)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (24857937..24891959)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15361 Neighboring gene sperm adhesion molecule 1 Neighboring gene sperm adhesion molecule 1 pseudogene Neighboring gene predicted gene, 22267 Neighboring gene STARR-seq mESC enhancer starr_15363 Neighboring gene STARR-seq mESC enhancer starr_15364 Neighboring gene STARR-seq mESC enhancer starr_15365 Neighboring gene transmembrane protein 229A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hyalurononglucosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hyalurononglucosaminidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IEA
Inferred from Electronic Annotation
more info
 
involved_in hyaluronan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within penetration of zona pellucida IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hyaluronidase-5
Names
hyal-5
hyaluronidase Hyal-5
hyaluronidase PH-20
NP_001404776.1
NP_001404777.1
NP_001404778.1
NP_083233.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417847.1NP_001404776.1  hyaluronidase-5 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC127559
    UniProtKB/Swiss-Prot
    Q812F3
    Related
    ENSMUSP00000031689.6, ENSMUST00000031689.6
  2. NM_001417848.1NP_001404777.1  hyaluronidase-5 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC127559
  3. NM_001417849.1NP_001404778.1  hyaluronidase-5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC127559
  4. NM_028957.3NP_083233.1  hyaluronidase-5 isoform a precursor

    See identical proteins and their annotated locations for NP_083233.1

    Status: VALIDATED

    Source sequence(s)
    AC127559
    Consensus CDS
    CCDS19948.1
    UniProtKB/Swiss-Prot
    Q812F3
    UniProtKB/TrEMBL
    Q9CUA5
    Related
    ENSMUSP00000144011.2, ENSMUST00000200968.4
    Conserved Domains (1) summary
    pfam01630
    Location:42369
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    24857982..24891963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)