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TRPV1 transient receptor potential cation channel subfamily V member 1 [ Homo sapiens (human) ]

Gene ID: 7442, updated on 1-Mar-2024

Summary

Official Symbol
TRPV1provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily V member 1provided by HGNC
Primary source
HGNC:HGNC:12716
See related
Ensembl:ENSG00000196689 MIM:602076; AllianceGenome:HGNC:12716
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VR1
Summary
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 3.6), ovary (RPKM 3.0) and 25 other tissues See more
Orthologs
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Genomic context

See TRPV1 in Genome Data Viewer
Location:
17p13.2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3565446..3609411, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3454482..3498442, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3468740..3512705, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 22 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:3386038-3386583 Neighboring gene aspartoacylase Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:3413293-3413831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3427509-3428008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3430899-3431819 Neighboring gene transient receptor potential cation channel subfamily V member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3457379-3457880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8013 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr17:3461306-3462122 and GRCh37_chr17:3462123-3462937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11510 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3466934-3467732 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:3478292-3479491 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3497604-3498104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3512595-3513096 Neighboring gene pterin-4 alpha-carbinolamine dehydratase 2 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:3526895-3528094 Neighboring gene sedoheptulokinase Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:3537096-3537961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8015 Neighboring gene uncharacterized LOC105371493 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:3543723-3544266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3557631-3558349 Neighboring gene cystinosin, lysosomal cystine transporter

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp434K0220

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel activity TAS
Traceable Author Statement
more info
 
enables calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chloride channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables excitatory extracellular ligand-gated monoatomic ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables extracellular ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables temperature-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated calcium channel activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in behavioral response to pain IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to ATP ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to alkaloid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to temperature stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in chemosensory behavior TAS
Traceable Author Statement
more info
PubMed 
involved_in detection of chemical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of temperature stimulus involved in thermoception IEA
Inferred from Electronic Annotation
more info
 
involved_in diet induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in fever generation IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of establishment of blood-brain barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to capsazepine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to capsazepine ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle contraction involved in micturition IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within thermoception IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in dendritic spine membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily V member 1
Names
OTRPC1
capsaicin receptor
osm-9-like TRP channel 1
transient receptor potential vanilloid 1a
transient receptor potential vanilloid 1b
vanilloid receptor subtype 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029716.2 RefSeqGene

    Range
    5000..48965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018727.5NP_061197.4  transient receptor potential cation channel subfamily V member 1

    See identical proteins and their annotated locations for NP_061197.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    A2RUA9, Q3LU47, Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22
    UniProtKB/TrEMBL
    Q09HS5
    Related
    ENSP00000461007.1, ENST00000571088.5
    Conserved Domains (3) summary
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:202232
    ANK; ANK repeat [structural motif]
  2. NM_080704.4NP_542435.2  transient receptor potential cation channel subfamily V member 1

    See identical proteins and their annotated locations for NP_542435.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    A2RUA9, Q3LU47, Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22
    UniProtKB/TrEMBL
    Q09HS5
    Related
    ENSP00000459962.1, ENST00000572705.2
    Conserved Domains (3) summary
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:202232
    ANK; ANK repeat [structural motif]
  3. NM_080705.4NP_542436.2  transient receptor potential cation channel subfamily V member 1

    See identical proteins and their annotated locations for NP_542436.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    A2RUA9, Q3LU47, Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22
    UniProtKB/TrEMBL
    Q09HS5
    Related
    ENSP00000382661.3, ENST00000399759.7
    Conserved Domains (3) summary
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:202232
    ANK; ANK repeat [structural motif]
  4. NM_080706.3NP_542437.2  transient receptor potential cation channel subfamily V member 1

    See identical proteins and their annotated locations for NP_542437.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AJ277028, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    A2RUA9, Q3LU47, Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22
    UniProtKB/TrEMBL
    Q09HS5
    Related
    ENSP00000382659.4, ENST00000399756.8
    Conserved Domains (3) summary
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:202232
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3565446..3609411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3454482..3498442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)