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TRPV1 transient receptor potential cation channel subfamily V member 1 [ Homo sapiens (human) ]

Gene ID: 7442, updated on 5-Aug-2018

Summary

Official Symbol
TRPV1provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily V member 1provided by HGNC
Primary source
HGNC:HGNC:12716
See related
Ensembl:ENSG00000196689 MIM:602076; Vega:OTTHUMG00000177649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VR1
Summary
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 3.6), ovary (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See TRPV1 in Genome Data Viewer
Location:
17p13.2
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (3565446..3609411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3468740..3512705, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 22 Neighboring gene aspartoacylase Neighboring gene transient receptor potential cation channel subfamily V member 3 Neighboring gene pterin-4 alpha-carbinolamine dehydratase 2 pseudogene Neighboring gene sedoheptulokinase Neighboring gene uncharacterized LOC105371493 Neighboring gene cystinosin, lysosomal cystine transporter

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434K0220

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium channel activity TAS
Traceable Author Statement
more info
 
calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chloride channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
excitatory extracellular ligand-gated ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular ligand-gated ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
temperature-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
behavioral response to pain IEA
Inferred from Electronic Annotation
more info
 
calcium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to ATP ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to alkaloid ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to temperature stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
chemosensory behavior TAS
Traceable Author Statement
more info
PubMed 
detection of chemical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
detection of temperature stimulus involved in thermoception IEA
Inferred from Electronic Annotation
more info
 
diet induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
fever generation IEA
Inferred from Electronic Annotation
more info
 
glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of establishment of blood-brain barrier IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
peptide secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
response to capsazepine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to capsazepine ISS
Inferred from Sequence or Structural Similarity
more info
 
response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
sensory perception of mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction involved in micturition IEA
Inferred from Electronic Annotation
more info
 
thermoception IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
dendritic spine membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily V member 1
Names
OTRPC1
capsaicin receptor
osm-9-like TRP channel 1
transient receptor potential vanilloid 1a
transient receptor potential vanilloid 1b
vanilloid receptor subtype 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029716.1 RefSeqGene

    Range
    5001..48966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_018727.5NP_061197.4  transient receptor potential cation channel subfamily V member 1

    See identical proteins and their annotated locations for NP_061197.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    Q8NER1
    Related
    ENSP00000461007.1, OTTHUMP00000257339, ENST00000571088.5, OTTHUMT00000438254
    Conserved Domains (3) summary
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:202232
    ANK; ANK repeat [structural motif]
  2. NM_080704.3NP_542435.2  transient receptor potential cation channel subfamily V member 1

    See identical proteins and their annotated locations for NP_542435.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    Q8NER1
    Related
    ENSP00000459962.1, OTTHUMP00000257344, ENST00000572705.1, OTTHUMT00000438261
    Conserved Domains (3) summary
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:202232
    ANK; ANK repeat [structural motif]
  3. NM_080705.3NP_542436.2  transient receptor potential cation channel subfamily V member 1

    See identical proteins and their annotated locations for NP_542436.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    Q8NER1
    Related
    ENSP00000382661.3, OTTHUMP00000257338, ENST00000399759.7, OTTHUMT00000438253
    Conserved Domains (3) summary
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:202232
    ANK; ANK repeat [structural motif]
  4. NM_080706.3NP_542437.2  transient receptor potential cation channel subfamily V member 1

    See identical proteins and their annotated locations for NP_542437.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC027796, AF196175, AJ272063, AJ277028, AL136801
    Consensus CDS
    CCDS45576.1
    UniProtKB/Swiss-Prot
    Q8NER1
    Related
    ENSP00000382659.4, OTTHUMP00000257340, ENST00000399756.8, OTTHUMT00000438255
    Conserved Domains (3) summary
    cd00204
    Location:200354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:52825
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:202232
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    3565446..3609411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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