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MPPED2 metallophosphoesterase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 744, updated on 11-Jun-2021

Summary

Official Symbol
MPPED2provided by HGNC
Official Full Name
metallophosphoesterase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:1180
See related
Ensembl:ENSG00000066382 MIM:600911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
239FB; C11orf8
Summary
This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Expression
Biased expression in thyroid (RPKM 4.7), prostate (RPKM 2.5) and 11 other tissues See more
Orthologs
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Genomic context

See MPPED2 in Genome Data Viewer
Location:
11p14.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (30384079..30586995, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (30405626..30607900, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723403 Neighboring gene ribosomal protein L12 pseudogene 30 Neighboring gene MPPED2 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 2859 Neighboring gene uncharacterized LOC101928338 Neighboring gene uncharacterized LOC107984419

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association and functional follow-up reveals new loci for kidney function.
GeneReviews: Not available
Genome-wide association scan for childhood caries implicates novel genes.
GeneReviews: Not available
Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
GeneReviews: Not available
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoric diester hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
metallophosphoesterase MPPED2
Names
fetal brain protein 239
metallophosphoesterase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145399.3NP_001138871.1  metallophosphoesterase MPPED2 isoform 2

    See identical proteins and their annotated locations for NP_001138871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' and the 3' UTR and contains an alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 7 both encode the same isoform (2).
    Source sequence(s)
    AL136088, AL353699, AL356240
    Consensus CDS
    CCDS44560.1
    UniProtKB/Swiss-Prot
    Q15777
    Related
    ENSP00000388258.2, ENST00000448418.6
    Conserved Domains (1) summary
    cd07379
    Location:59255
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
  2. NM_001377952.1NP_001364881.1  metallophosphoesterase MPPED2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 4-6, encodes isoform 1.
    Source sequence(s)
    AL136088, AL353699, AL356240
    Conserved Domains (1) summary
    cd07379
    Location:59271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
  3. NM_001377953.1NP_001364882.1  metallophosphoesterase MPPED2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 3, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AL136088, AL353699, AL356240
    Conserved Domains (1) summary
    cd07379
    Location:59271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
  4. NM_001377954.1NP_001364883.1  metallophosphoesterase MPPED2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 3, 4, and 6, encodes isoform 1.
    Source sequence(s)
    AL136088, AL353699, AL356240
    Conserved Domains (1) summary
    cd07379
    Location:59271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
  5. NM_001377955.1NP_001364884.1  metallophosphoesterase MPPED2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1 and 3-5, encodes isoform 1.
    Source sequence(s)
    AL136088, AL353699, AL356240
    Conserved Domains (1) summary
    cd07379
    Location:59271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
  6. NM_001377956.1NP_001364885.1  metallophosphoesterase MPPED2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AL136088, AL353699, AL356240
    Conserved Domains (1) summary
    cd07379
    Location:59255
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
  7. NM_001584.3NP_001575.1  metallophosphoesterase MPPED2 isoform 1

    See identical proteins and their annotated locations for NP_001575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3-6 all encode the same isoform (1).
    Source sequence(s)
    AL136088, AL353699, AL356240
    Consensus CDS
    CCDS7870.1
    UniProtKB/Swiss-Prot
    Q15777
    Related
    ENSP00000350833.4, ENST00000358117.10
    Conserved Domains (1) summary
    cd07379
    Location:59271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

RNA

  1. NR_165336.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  2. NR_165337.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  3. NR_165338.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  4. NR_165339.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  5. NR_165340.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  6. NR_165341.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  7. NR_165342.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  8. NR_165343.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  9. NR_165344.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  10. NR_165345.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  11. NR_165346.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  12. NR_165347.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240
  13. NR_165348.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136088, AL353699, AL356240

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    30384079..30586995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448676.1XP_024304444.1  metallophosphoesterase MPPED2 isoform X1

    Conserved Domains (1) summary
    cd07379
    Location:59271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
  2. XM_005253111.2XP_005253168.1  metallophosphoesterase MPPED2 isoform X1

    See identical proteins and their annotated locations for XP_005253168.1

    UniProtKB/Swiss-Prot
    Q15777
    Conserved Domains (1) summary
    cd07379
    Location:59271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
  3. XM_017018231.1XP_016873720.1  metallophosphoesterase MPPED2 isoform X2

  4. XM_005253114.4XP_005253171.1  metallophosphoesterase MPPED2 isoform X5

    Conserved Domains (2) summary
    COG1409
    Location:59120
    CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]
    cd07379
    Location:59125
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
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