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Hnrnpr heterogeneous nuclear ribonucleoprotein R [ Mus musculus (house mouse) ]

Gene ID: 74326, updated on 5-Feb-2023

Summary

Official Symbol
Hnrnprprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Rprovided by MGI
Primary source
MGI:MGI:1891692
See related
Ensembl:ENSMUSG00000066037 AllianceGenome:MGI:1891692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpr; 2610003J05Rik; 2610528B01Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA destabilization and negative regulation of catalytic activity. Located in nucleus. Is expressed in central nervous system; limb; sensory organ; and thymus. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 21.4), CNS E14 (RPKM 17.4) and 21 other tissues See more
Orthologs
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Genomic context

See Hnrnpr in Genome Data Viewer
Location:
4; 4 D3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136038230..136086758)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136310942..136345981)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene zinc finger protein 46 Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1D

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277121.1NP_001264050.1  heterogeneous nuclear ribonucleoprotein R isoform a

    See identical proteins and their annotated locations for NP_001264050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
    Source sequence(s)
    AK138916, AK152039, AL670673, AL935264, AW060625, BX537311
    Consensus CDS
    CCDS18805.1
    UniProtKB/TrEMBL
    Q3U8W9, Q8VHM5
    Related
    ENSMUSP00000101476.2, ENSMUST00000105850.8
    Conserved Domains (2) summary
    TIGR01648
    Location:106627
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
  2. NM_001277122.1NP_001264051.1  heterogeneous nuclear ribonucleoprotein R isoform b

    See identical proteins and their annotated locations for NP_001264051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AK133840, AK138916, AL670673, AL935264, AW060625, BX537311, BY311081
    Consensus CDS
    CCDS71495.1
    UniProtKB/TrEMBL
    F7B5B5, Q3UZI0
    Related
    ENSMUSP00000081239.6, ENSMUST00000084219.12
    Conserved Domains (1) summary
    TIGR01648
    Location:5526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  3. NM_001277123.1NP_001264052.1  heterogeneous nuclear ribonucleoprotein R isoform b

    See identical proteins and their annotated locations for NP_001264052.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AK138916, AK145849, AL670673, AL935264, AW060625, BX537311
    Consensus CDS
    CCDS71495.1
    UniProtKB/TrEMBL
    F7B5B5, Q3UKV5
    Related
    ENSMUSP00000138263.2, ENSMUST00000131671.8
    Conserved Domains (1) summary
    TIGR01648
    Location:5526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  4. NM_001355182.1NP_001342111.1  heterogeneous nuclear ribonucleoprotein R isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
    Source sequence(s)
    AK138916, AK152039, AL670673, AL935264, AW060625, BB841005, BX537311, BY138716
    Consensus CDS
    CCDS18805.1
    UniProtKB/TrEMBL
    Q8VHM5
    Conserved Domains (2) summary
    TIGR01648
    Location:106627
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
  5. NM_028871.2NP_083147.1  heterogeneous nuclear ribonucleoprotein R isoform a

    See identical proteins and their annotated locations for NP_083147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2 and 6 encode the same isoform (a).
    Source sequence(s)
    AK138916, AK145849, AK147043, AL670673, AL935264, AW060625, BX537311
    Consensus CDS
    CCDS18805.1
    UniProtKB/TrEMBL
    Q3UKV5, Q8VHM5
    Related
    ENSMUSP00000138399.2, ENSMUST00000148843.10
    Conserved Domains (2) summary
    TIGR01648
    Location:106627
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136038230..136086758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539228.5XP_006539291.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    See identical proteins and their annotated locations for XP_006539291.1

    Conserved Domains (1) summary
    TIGR01648
    Location:5529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  2. XM_006539222.3XP_006539285.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    See identical proteins and their annotated locations for XP_006539285.1

    Conserved Domains (2) summary
    TIGR01648
    Location:106630
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
  3. XM_036164497.1XP_036020390.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5
    Conserved Domains (1) summary
    TIGR01648
    Location:5526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  4. XM_006539223.5XP_006539286.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    See identical proteins and their annotated locations for XP_006539286.1

    Conserved Domains (2) summary
    TIGR01648
    Location:106630
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
  5. XM_030253846.2XP_030109706.1  heterogeneous nuclear ribonucleoprotein R isoform X2

    UniProtKB/TrEMBL
    Q8VHM5
    Conserved Domains (2) summary
    TIGR01648
    Location:106627
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
  6. XM_030253848.2XP_030109708.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    Conserved Domains (1) summary
    TIGR01648
    Location:5529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  7. XM_030253850.2XP_030109710.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5
    Conserved Domains (1) summary
    TIGR01648
    Location:5526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  8. XM_006539226.3XP_006539289.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    See identical proteins and their annotated locations for XP_006539289.1

    Conserved Domains (1) summary
    TIGR01648
    Location:5529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  9. XM_006539227.2XP_006539290.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    See identical proteins and their annotated locations for XP_006539290.1

    Conserved Domains (1) summary
    TIGR01648
    Location:5529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  10. XM_006539225.5XP_006539288.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    See identical proteins and their annotated locations for XP_006539288.1

    Conserved Domains (1) summary
    TIGR01648
    Location:5529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  11. XM_030253849.2XP_030109709.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5
    Conserved Domains (1) summary
    TIGR01648
    Location:5526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  12. XM_036164499.1XP_036020392.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5
    Conserved Domains (1) summary
    TIGR01648
    Location:5526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
  13. XM_006539224.5XP_006539287.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    See identical proteins and their annotated locations for XP_006539287.1

    Conserved Domains (2) summary
    TIGR01648
    Location:106630
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain
  14. XM_036164498.1XP_036020391.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5
    Conserved Domains (1) summary
    TIGR01648
    Location:5526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

RNA

  1. XR_004941997.1 RNA Sequence