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Hnrnpr heterogeneous nuclear ribonucleoprotein R [ Mus musculus (house mouse) ]

Gene ID: 74326, updated on 2-Nov-2024

Summary

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Official Symbol
Hnrnprprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Rprovided by MGI
Primary source
MGI:MGI:1891692
See related
Ensembl:ENSMUSG00000066037 AllianceGenome:MGI:1891692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpr; 2610003J05Rik; 2610528B01Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA destabilization. Located in nucleus. Is expressed in central nervous system; jaw; limb; sensory organ; and thymus. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 21.4), CNS E14 (RPKM 17.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Hnrnpr in Genome Data Viewer
Location:
4 D3; 4 68.4 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136038230..136086758)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136310942..136345981)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene STARR-positive B cell enhancer ABC_E9604 Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene STARR-positive B cell enhancer ABC_E4689 Neighboring gene zinc finger protein 46 Neighboring gene STARR-seq mESC enhancer starr_11754 Neighboring gene STARR-seq mESC enhancer starr_11755 Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis. Zare A, et al. Nat Commun, 2024 Aug 28. PMID 39198412, Free PMC Article
  2. hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons. Briese M, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507242, Free PMC Article
  3. Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr. Salehi S, et al. Nat Commun, 2023 Jul 12. PMID 37438340, Free PMC Article
  4. Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin. Ghanawi H, et al. Nucleic Acids Res, 2021 Dec 2. PMID 34850154, Free PMC Article
  5. Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene. Fukuda A, et al. PLoS One, 2013. PMID 23967313, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis.
    Title: hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis.
  2. Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.
    Title: Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin.
  3. HnRNP R shapes the axonal transcriptome and its activity toward RNA localization is intricately linked to its main binding partner, noncoding RNA 7SK.
    Title: hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons.
  4. Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene.
    Title: Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene.
  5. HnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation.
    Title: The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277121.1 → NP_001264050.1  heterogeneous nuclear ribonucleoprotein R isoform a

    See identical proteins and their annotated locations for NP_001264050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
    Source sequence(s)
    AK138916, AK152039, AL670673, AL935264, AW060625, BX537311
    Consensus CDS
    CCDS18805.1
    UniProtKB/TrEMBL
    Q3UMT8, Q8VHM5
    Related
    ENSMUSP00000101476.2, ENSMUST00000105850.8
    Conserved Domains (2) summary
    TIGR01648
    Location:106 → 627
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37 → 106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

  2. NM_001277122.1 → NP_001264051.1  heterogeneous nuclear ribonucleoprotein R isoform b

    See identical proteins and their annotated locations for NP_001264051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AK133840, AK138916, AL670673, AL935264, AW060625, BX537311, BY311081
    Consensus CDS
    CCDS71495.1
    UniProtKB/TrEMBL
    F7B5B5, Q99KG1
    Related
    ENSMUSP00000081239.6, ENSMUST00000084219.12
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  3. NM_001277123.1 → NP_001264052.1  heterogeneous nuclear ribonucleoprotein R isoform b

    See identical proteins and their annotated locations for NP_001264052.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AK138916, AK145849, AL670673, AL935264, AW060625, BX537311
    Consensus CDS
    CCDS71495.1
    UniProtKB/TrEMBL
    F7B5B5, Q99KG1
    Related
    ENSMUSP00000138263.2, ENSMUST00000131671.8
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  4. NM_001355182.1 → NP_001342111.1  heterogeneous nuclear ribonucleoprotein R isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode the same isoform (a).
    Source sequence(s)
    AK138916, AK152039, AL670673, AL935264, AW060625, BB841005, BX537311, BY138716
    Consensus CDS
    CCDS18805.1
    UniProtKB/TrEMBL
    Q3UMT8, Q8VHM5
    Conserved Domains (2) summary
    TIGR01648
    Location:106 → 627
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37 → 106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

  5. NM_028871.2 → NP_083147.1  heterogeneous nuclear ribonucleoprotein R isoform a

    See identical proteins and their annotated locations for NP_083147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2 and 6 encode the same isoform (a).
    Source sequence(s)
    AK138916, AK145849, AK147043, AL670673, AL935264, AW060625, BX537311
    Consensus CDS
    CCDS18805.1
    UniProtKB/TrEMBL
    Q3UMT8, Q8VHM5
    Related
    ENSMUSP00000138399.2, ENSMUST00000148843.10
    Conserved Domains (2) summary
    TIGR01648
    Location:106 → 627
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37 → 106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136038230..136086758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539228.5 → XP_006539291.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    See identical proteins and their annotated locations for XP_006539291.1

    UniProtKB/TrEMBL
    Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  2. XM_006539222.3 → XP_006539285.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    See identical proteins and their annotated locations for XP_006539285.1

    UniProtKB/TrEMBL
    Q3UMT8
    Conserved Domains (2) summary
    TIGR01648
    Location:106 → 630
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37 → 106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

  3. XM_036164497.1 → XP_036020390.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5, Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  4. XM_006539223.5 → XP_006539286.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    See identical proteins and their annotated locations for XP_006539286.1

    UniProtKB/TrEMBL
    Q3UMT8
    Conserved Domains (2) summary
    TIGR01648
    Location:106 → 630
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37 → 106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

  5. XM_030253846.2 → XP_030109706.1  heterogeneous nuclear ribonucleoprotein R isoform X2

    UniProtKB/TrEMBL
    Q3UMT8, Q8VHM5
    Conserved Domains (2) summary
    TIGR01648
    Location:106 → 627
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37 → 106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

  6. XM_030253848.2 → XP_030109708.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    UniProtKB/TrEMBL
    Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  7. XM_030253850.2 → XP_030109710.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5, Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  8. XM_006539226.3 → XP_006539289.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    See identical proteins and their annotated locations for XP_006539289.1

    UniProtKB/TrEMBL
    Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  9. XM_006539227.2 → XP_006539290.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    See identical proteins and their annotated locations for XP_006539290.1

    UniProtKB/TrEMBL
    Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  10. XM_006539225.5 → XP_006539288.1  heterogeneous nuclear ribonucleoprotein R isoform X3

    See identical proteins and their annotated locations for XP_006539288.1

    UniProtKB/TrEMBL
    Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 529
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  11. XM_030253849.2 → XP_030109709.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5, Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  12. XM_036164499.1 → XP_036020392.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5, Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  13. XM_006539224.5 → XP_006539287.1  heterogeneous nuclear ribonucleoprotein R isoform X1

    See identical proteins and their annotated locations for XP_006539287.1

    UniProtKB/TrEMBL
    Q3UMT8
    Conserved Domains (2) summary
    TIGR01648
    Location:106 → 630
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    pfam18360
    Location:37 → 106
    hnRNP_Q_AcD; Heterogeneous nuclear ribonucleoprotein Q acidic domain

  14. XM_036164498.1 → XP_036020391.1  heterogeneous nuclear ribonucleoprotein R isoform X4

    UniProtKB/TrEMBL
    F7B5B5, Q99KG1
    Conserved Domains (1) summary
    TIGR01648
    Location:5 → 526
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

RNA

  1. XR_004941997.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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