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Mettl23 methyltransferase like 23 [ Mus musculus (house mouse) ]

Gene ID: 74319, updated on 24-Jan-2023

Summary

Official Symbol
Mettl23provided by MGI
Official Full Name
methyltransferase like 23provided by MGI
Primary source
MGI:MGI:1921569
See related
Ensembl:ENSMUSG00000090266 AllianceGenome:MGI:1921569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110005A03Rik; 1500035B17Rik; 4933424L15Rik
Summary
Predicted to enable DNA-binding transcription factor binding activity and heat shock protein binding activity. Predicted to be involved in cognition and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within methylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human METTL23 (methyltransferase like 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 16.8), mammary gland adult (RPKM 12.1) and 28 other tissues See more
Orthologs
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Genomic context

See Mettl23 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116734341..116740566)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116843515..116849740)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Neighboring gene matrix-remodelling associated 7 Neighboring gene jumonji domain containing 6 Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene serine and arginine-rich splicing factor 2 Neighboring gene mannoside acetylglucosaminyltransferase 5, isoenzyme B Neighboring gene predicted gene, 33829

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H3R17 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-arginine omega-N asymmetric methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in female pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in male pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone-arginine methyltransferase METTL23; methyltransferase-like protein 23
Names
probable methyltransferase-like protein 23
NP_083141.3
XP_006534423.1
XP_036012939.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028865.3NP_083141.3  histone-arginine methyltransferase METTL23

    See identical proteins and their annotated locations for NP_083141.3

    Status: VALIDATED

    Source sequence(s)
    AK003450, AW490033, BY122329
    Consensus CDS
    CCDS25679.2
    UniProtKB/Swiss-Prot
    A2AA28, Q9D1J5
    Related
    ENSMUSP00000101978.4, ENSMUST00000106370.10
    Conserved Domains (1) summary
    cl17173
    Location:63189
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116734341..116740566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534360.4XP_006534423.1  methyltransferase-like protein 23 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:3126
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_036157046.1XP_036012939.1  methyltransferase-like protein 23 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:3126
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...