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Mtmr3 myotubularin related protein 3 [ Mus musculus (house mouse) ]

Gene ID: 74302, updated on 6-Sep-2019

Summary

Official Symbol
Mtmr3provided by MGI
Official Full Name
myotubularin related protein 3provided by MGI
Primary source
MGI:MGI:1921552
See related
Ensembl:ENSMUSG00000034354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFYVE10; AI255150; AW557713; FYVE-DSP1; mKIAA0371; 1700092A20Rik
Expression
Ubiquitous expression in bladder adult (RPKM 14.9), thymus adult (RPKM 14.6) and 28 other tissues See more
Orthologs

Genomic context

See Mtmr3 in Genome Data Viewer
Location:
11; 11 A1
Exon count:
22
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4480867..4594863, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4380871..4494818, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene HORMA domain containing 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 11961 Neighboring gene activating signal cointegrator 1 complex subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC78036

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 5-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myotubularin-related protein 3
Names
phosphatidylinositol-3,5-bisphosphate 3-phosphatase
phosphatidylinositol-3-phosphate phosphatase
NP_083136.2
XP_006514908.1
XP_006514909.1
XP_006514910.1
XP_006514911.1
XP_017170296.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373897.1NP_001360826.1  myotubularin-related protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606521, AL645910
  2. NM_028860.2NP_083136.2  myotubularin-related protein 3 isoform 2

    See identical proteins and their annotated locations for NP_083136.2

    Status: VALIDATED

    Source sequence(s)
    AK122261, AK141138, AW046647, CB249296, CB527330, CF532066, CJ048010, CV557784, CX566279
    Consensus CDS
    CCDS48744.1
    UniProtKB/TrEMBL
    B1ATD5, Q80U24
    Related
    ENSMUSP00000105569.3, ENSMUST00000109943.9
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:10761136
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    pfam06602
    Location:127523
    Myotub-related; Myotubularin-like phosphatase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    4480867..4594863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514848.4XP_006514911.1  myotubularin-related protein 3 isoform X3

    Related
    ENSMUSP00000116315.1, ENSMUST00000128256.1
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:10761145
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    pfam06602
    Location:127523
    Myotub-related; Myotubularin-like phosphatase domain
  2. XM_006514847.4XP_006514910.1  myotubularin-related protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q8K296
    Related
    ENSMUSP00000122422.1, ENSMUST00000123506.7
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:11131173
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    pfam06602
    Location:127523
    Myotub-related; Myotubularin-like phosphatase domain
  3. XM_006514845.4XP_006514908.1  myotubularin-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006514908.1

    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:11131182
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    pfam06602
    Location:127523
    Myotub-related; Myotubularin-like phosphatase domain
  4. XM_006514846.4XP_006514909.1  myotubularin-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006514909.1

    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:11131182
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    pfam06602
    Location:127523
    Myotub-related; Myotubularin-like phosphatase domain
  5. XM_017314807.2XP_017170296.1  myotubularin-related protein 3 isoform X4

RNA

  1. XR_003949519.1 RNA Sequence

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