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Mtmr3 myotubularin related protein 3 [ Mus musculus (house mouse) ]

Gene ID: 74302, updated on 5-Mar-2024

Summary

Official Symbol
Mtmr3provided by MGI
Official Full Name
myotubularin related protein 3provided by MGI
Primary source
MGI:MGI:1921552
See related
Ensembl:ENSMUSG00000034354 AllianceGenome:MGI:1921552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFYVE10; FYVE-DSP1; mKIAA0371; 1700092A20Rik
Summary
Predicted to enable phosphatase activity and protein phosphatase binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; phosphatidylinositol metabolic process; and regulation of phosphatidylinositol dephosphorylation. Predicted to act upstream of or within lipid metabolic process. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 14.9), thymus adult (RPKM 14.6) and 28 other tissues See more
Orthologs
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Genomic context

See Mtmr3 in Genome Data Viewer
Location:
11 A1; 11 2.94 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4430867..4544863, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4480867..4594863, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24803 Neighboring gene HORMA domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_28383 Neighboring gene STARR-seq mESC enhancer starr_28385 Neighboring gene STARR-positive B cell enhancer ABC_E5204 Neighboring gene STARR-seq mESC enhancer starr_28386 Neighboring gene STARR-seq mESC enhancer starr_28391 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E728 Neighboring gene STARR-positive B cell enhancer ABC_E3930 Neighboring gene predicted gene 11961 Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_28397

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC78036

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol 5-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myotubularin-related protein 3
Names
phosphatidylinositol-3,5-bisphosphate 3-phosphatase
phosphatidylinositol-3-phosphate phosphatase
NP_001360826.1
NP_083136.2
XP_006514908.1
XP_006514909.1
XP_006514911.1
XP_036012929.1
XP_036012930.1
XP_036012931.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373897.1NP_001360826.1  myotubularin-related protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606521, AL645910
    UniProtKB/Swiss-Prot
    Q5NCA4, Q8K296
    UniProtKB/TrEMBL
    R4GML8
    Related
    ENSMUSP00000122422.2, ENSMUST00000123506.8
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:11131173
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
  2. NM_028860.2NP_083136.2  myotubularin-related protein 3 isoform 2

    See identical proteins and their annotated locations for NP_083136.2

    Status: VALIDATED

    Source sequence(s)
    AK122261, AK141138, AW046647, CB249296, CB527330, CF532066, CJ048010, CV557784, CX566279
    Consensus CDS
    CCDS48744.1
    UniProtKB/TrEMBL
    B1ATD5, Q66I45
    Related
    ENSMUSP00000105569.4, ENSMUST00000109943.10
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:10761136
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4430867..4544863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157038.1XP_036012931.1  myotubularin-related protein 3 isoform X4

    UniProtKB/TrEMBL
    M0QW74
    Related
    ENSMUSP00000137687.2, ENSMUST00000130716.8
    Conserved Domains (2) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd14586
    Location:169485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
  2. XM_006514848.4XP_006514911.1  myotubularin-related protein 3 isoform X2

    UniProtKB/TrEMBL
    B1ATD4
    Related
    ENSMUSP00000116315.2, ENSMUST00000128256.2
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:10761145
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
  3. XM_006514845.4XP_006514908.1  myotubularin-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006514908.1

    UniProtKB/TrEMBL
    R4GML8
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:11131182
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
  4. XM_006514846.4XP_006514909.1  myotubularin-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006514909.1

    UniProtKB/TrEMBL
    R4GML8
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:11131182
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
  5. XM_036157036.1XP_036012929.1  myotubularin-related protein 3 isoform X1

    UniProtKB/TrEMBL
    R4GML8
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:11131182
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
  6. XM_036157037.1XP_036012930.1  myotubularin-related protein 3 isoform X3

    UniProtKB/TrEMBL
    B1ATD5, Q66I45
    Related
    ENSMUSP00000049079.7, ENSMUST00000040448.13
    Conserved Domains (3) summary
    cd13341
    Location:23116
    PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd15732
    Location:10761136
    FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
    cd14586
    Location:169485
    PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

RNA

  1. XR_003949519.1 RNA Sequence