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VIL1 villin 1 [ Homo sapiens (human) ]

Gene ID: 7429, updated on 5-Jan-2022

Summary

Official Symbol
VIL1provided by HGNC
Official Full Name
villin 1provided by HGNC
Primary source
HGNC:HGNC:12690
See related
Ensembl:ENSG00000127831 MIM:193040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VIL; D2S1471
Summary
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 141.0), duodenum (RPKM 126.6) and 3 other tissues See more
Orthologs
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Genomic context

See VIL1 in Genome Data Viewer
Location:
2q35
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218419123..218453295)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219283846..219318018)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 member 1 Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene Sharpr-MPRA regulatory region 3568 Neighboring gene ubiquitin specific peptidase 37 Neighboring gene RN7SK pseudogene 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lysophosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament capping IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin filament severing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin nucleation IEA
Inferred from Electronic Annotation
more info
 
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in barbed-end actin filament capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hepatocyte growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic actin-based contraction involved in cell motility IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in intestinal D-glucose absorption IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of actin filament depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lamellipodium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of actin nucleation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of lamellipodium morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of lamellipodium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of microvillus length IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in terminal web assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin filament bundle IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium tip ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007127.3NP_009058.2  villin-1

    See identical proteins and their annotated locations for NP_009058.2

    Status: REVIEWED

    Source sequence(s)
    AC073838, AK223398, AK313709, BP329402
    Consensus CDS
    CCDS2417.1
    UniProtKB/Swiss-Prot
    P09327
    UniProtKB/TrEMBL
    Q53F91
    Related
    ENSP00000248444.5, ENST00000248444.10
    Conserved Domains (7) summary
    cd11288
    Location:513603
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17121
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:619715
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:250348
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:392492
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:793827
    VHP; Villin headpiece domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218419123..218453295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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