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Sipa1l3 signal-induced proliferation-associated 1 like 3 [ Mus musculus (house mouse) ]

Gene ID: 74206, updated on 18-Apr-2024

Summary

Official Symbol
Sipa1l3provided by MGI
Official Full Name
signal-induced proliferation-associated 1 like 3provided by MGI
Primary source
MGI:MGI:1921456
See related
Ensembl:ENSMUSG00000030583 AllianceGenome:MGI:1921456
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610511M17Rik
Summary
Predicted to enable GTPase activator activity. Involved in several processes, including epithelial cell morphogenesis; establishment of epithelial cell polarity; and eye development. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including nucleoplasm; stress fiber; and tricellular tight junction. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in lens vesicle. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 17.0), small intestine adult (RPKM 16.1) and 26 other tissues See more
Orthologs
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Genomic context

Location:
7 B1; 7 16.94 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29016687..29218694, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29320372..29519161, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45977 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14A Neighboring gene STARR-seq mESC enhancer starr_18467 Neighboring gene double PHD fingers 1 Neighboring gene STARR-seq mESC enhancer starr_18469 Neighboring gene STARR-seq mESC enhancer starr_18470 Neighboring gene STARR-seq mESC enhancer starr_18474 Neighboring gene STARR-seq mESC enhancer starr_18476 Neighboring gene RIKEN cDNA 4932431P20 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30303585-30303694 Neighboring gene RIKEN cDNA 4930432E11 gene Neighboring gene STARR-seq mESC enhancer starr_18479 Neighboring gene predicted gene, 38982

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 
located_in tricellular tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal-induced proliferation-associated 1-like protein 3
Names
SIPA1-like protein 3
SPA-1-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081028.1NP_001074497.1  signal-induced proliferation-associated 1-like protein 3

    See identical proteins and their annotated locations for NP_001074497.1

    Status: PROVISIONAL

    Source sequence(s)
    AC164640, AC166079
    Consensus CDS
    CCDS39871.1
    UniProtKB/Swiss-Prot
    G3X9J0
    Related
    ENSMUSP00000082965.5, ENSMUST00000085809.11
    Conserved Domains (4) summary
    PHA03247
    Location:10661706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29016687..29218694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250732.4XP_011249034.1  signal-induced proliferation-associated 1-like protein 3 isoform X3

    See identical proteins and their annotated locations for XP_011249034.1

    UniProtKB/Swiss-Prot
    G3X9J0
    Conserved Domains (4) summary
    PHA03247
    Location:10661706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  2. XM_006540405.4XP_006540468.1  signal-induced proliferation-associated 1-like protein 3 isoform X4

    Conserved Domains (4) summary
    PHA03247
    Location:10661705
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761720
    SPAR_C; C-terminal domain of SPAR protein
  3. XM_006540404.5XP_006540467.1  signal-induced proliferation-associated 1-like protein 3 isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:11311705
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761720
    SPAR_C; C-terminal domain of SPAR protein
  4. XM_011250727.4XP_011249029.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011249029.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  5. XM_017312346.3XP_017167835.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  6. XM_006540397.5XP_006540460.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006540460.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  7. XM_006540402.3XP_006540465.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006540465.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  8. XM_006540401.5XP_006540464.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006540464.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  9. XM_011250729.4XP_011249031.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011249031.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  10. XM_011250730.4XP_011249032.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011249032.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  11. XM_011250731.4XP_011249033.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011249033.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  12. XM_011250728.4XP_011249030.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011249030.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  13. XM_006540400.4XP_006540463.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006540463.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  14. XM_006540399.4XP_006540462.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006540462.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein
  15. XM_006540403.3XP_006540466.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006540466.1

    Conserved Domains (4) summary
    PHA03247
    Location:11311706
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9601030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:635815
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:14761721
    SPAR_C; C-terminal domain of SPAR protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028818.1: Suppressed sequence

    Description
    NM_028818.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.