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Elp3 elongator acetyltransferase complex subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 74195, updated on 2-Oct-2018

Summary

Official Symbol
Elp3provided by MGI
Official Full Name
elongator acetyltransferase complex subunit 3provided by MGI
Primary source
MGI:MGI:1921445
See related
Ensembl:ENSMUSG00000022031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAT9; 2610507P14Rik
Expression
Ubiquitous expression in CNS E18 (RPKM 31.8), CNS E14 (RPKM 30.9) and 28 other tissues See more
Orthologs

Genomic context

See Elp3 in Genome Data Viewer
Location:
14; 14 D1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (65530446..65593112, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66149293..66211847, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene prepronociceptin Neighboring gene RIKEN cDNA 9530047P18 gene Neighboring gene nuclear GTPase, germinal center associated Neighboring gene predicted gene, 30245 Neighboring gene scavenger receptor class A, member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphorylase kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Elongator holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
elongator complex protein 3
Names
elongation protein 3 homolog
NP_001240741.1
NP_083087.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253812.1NP_001240741.1  elongator complex protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001240741.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122274, AC158983
    Consensus CDS
    CCDS56965.1
    UniProtKB/Swiss-Prot
    Q9CZX0
    Related
    ENSMUSP00000022609.5, ENSMUST00000022609.6
    Conserved Domains (3) summary
    cd01335
    Location:115359
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR01211
    Location:56565
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    pfam16199
    Location:333411
    Radical_SAM_C; Radical_SAM C-terminal domain
  2. NM_028811.3NP_083087.1  elongator complex protein 3 isoform 2

    See identical proteins and their annotated locations for NP_083087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC122274, AC158983, AK012072
    UniProtKB/Swiss-Prot
    Q9CZX0
    Related
    ENSMUSP00000153462.1, ENSMUST00000225355.1
    Conserved Domains (3) summary
    cd01335
    Location:96340
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR01211
    Location:37546
    ELP3; radical SAM enzyme/protein acetyltransferase, ELP3 family
    pfam16199
    Location:314392
    Radical_SAM_C; Radical_SAM C-terminal domain

RNA

  1. NR_045599.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC122274, AC158983, AK150058
    Related
    ENSMUST00000224743.1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    65530446..65593112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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