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Perm1 PPARGC1 and ESRR induced regulator, muscle 1 [ Mus musculus (house mouse) ]

Gene ID: 74183, updated on 5-Mar-2024

Summary

Official Symbol
Perm1provided by MGI
Official Full Name
PPARGC1 and ESRR induced regulator, muscle 1provided by MGI
Primary source
MGI:MGI:1921433
See related
Ensembl:ENSMUSG00000078486 AllianceGenome:MGI:1921433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310042D19Rik
Summary
Involved in regulation of transcription, DNA-templated and response to muscle activity. Located in cytoplasm and nucleus. Is expressed in gastrocnemius muscle; heart; heart atrium; and heart ventricle. Orthologous to human PERM1 (PPARGC1 and ESRR induced regulator, muscle 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 66.5), stomach adult (RPKM 6.1) and 2 other tissues See more
Orthologs
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Genomic context

See Perm1 in Genome Data Viewer
Location:
4 E2; 4 88.62 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156287724..156305766)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156203262..156221307)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene agrin Neighboring gene STARR-seq mESC enhancer starr_12290 Neighboring gene predicted gene, 46878 Neighboring gene STARR-seq mESC enhancer starr_12291 Neighboring gene STARR-positive B cell enhancer ABC_E2735 Neighboring gene ISG15 ubiquitin-like modifier Neighboring gene expressed sequence AW011738 Neighboring gene predicted gene, 46877 Neighboring gene pleckstrin homology domain containing, family N member 1 Neighboring gene kelch-like 17 Neighboring gene microRNA 7658

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC143962, MGC143963

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to muscle activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to muscle activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to muscle activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
PGC-1 and ERR-induced regulator in muscle protein 1
Names
PGC-1 and ERR-induced regulator in muscle 1
PPARGC1 and ESRR-induced regulator in muscle 1
peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172417.3NP_766005.2  PGC-1 and ERR-induced regulator in muscle protein 1

    See identical proteins and their annotated locations for NP_766005.2

    Status: VALIDATED

    Source sequence(s)
    AI597030, AK009747, AK036660, BC117871
    Consensus CDS
    CCDS51406.1
    UniProtKB/Swiss-Prot
    E9QP35, Q149B8, Q8BS19, Q8CB71
    Related
    ENSMUSP00000101197.2, ENSMUST00000105572.3
    Conserved Domains (1) summary
    PHA03247
    Location:80578
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156287724..156305766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539212.5XP_006539275.1  PGC-1 and ERR-induced regulator in muscle protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006539275.1

    UniProtKB/Swiss-Prot
    E9QP35, Q149B8, Q8BS19, Q8CB71
    Conserved Domains (1) summary
    PHA03247
    Location:80578
    PHA03247; large tegument protein UL36; Provisional