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Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 74147, updated on 23-May-2018
Official Symbol
Ehhadhprovided by MGI
Official Full Name
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenaseprovided by MGI
Primary source
MGI:MGI:1277964
See related
Ensembl:ENSMUSG00000022853 Vega:OTTMUSG00000033863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HD; LBP; MFP; LBFP; MFP1; PBFE; L-PBE; 1300002P22Rik
Expression
Biased expression in liver E18 (RPKM 121.5), kidney adult (RPKM 92.4) and 8 other tissues See more
Orthologs
See Ehhadh in Genome Data Viewer
Location:
16; 16 B1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (21761285..21787834, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (21761358..21787907, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene VPS8 CORVET complex subunit Neighboring gene uncharacterized LOC108168286 Neighboring gene RIKEN cDNA 2510009E07 gene Neighboring gene RIKEN cDNA 1300002E11 gene Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 13

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3-hydroxyacyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
3-hydroxyacyl-CoA dehydrogenase activity TAS
Traceable Author Statement
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
dodecenoyl-CoA delta-isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enoyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
PubMed 
fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
internal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
 
peroxisome TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
peroxisomal bifunctional enzyme
Names
L-bifunctional enzyme
L-specific multifunctional beta-oxdiation protein
PBE
NP_076226.2
XP_006522721.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023737.3NP_076226.2  peroxisomal bifunctional enzyme

    See identical proteins and their annotated locations for NP_076226.2

    Status: VALIDATED

    Source sequence(s)
    AC130214, AK004867, BB841865
    Consensus CDS
    CCDS28063.1
    UniProtKB/Swiss-Prot
    Q9DBM2
    Related
    ENSMUSP00000023559.5, OTTMUSP00000046102, ENSMUST00000023559.5, OTTMUST00000085347
    Conserved Domains (4) summary
    cd06558
    Location:12186
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    PRK11154
    Location:20702
    fadJ; multifunctional fatty acid oxidation complex subunit alpha; Reviewed
    pfam00725
    Location:473577
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:297471
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    21761285..21787834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522658.3XP_006522721.1  peroxisomal bifunctional enzyme isoform X1

    Conserved Domains (4) summary
    COG1024
    Location:3218
    CaiD; Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]
    COG1250
    Location:238528
    FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
    pfam00725
    Location:417521
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:241415
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
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