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Traf3ip1 TRAF3 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 74019, updated on 8-May-2024

Summary

Official Symbol
Traf3ip1provided by MGI
Official Full Name
TRAF3 interacting protein 1provided by MGI
Primary source
MGI:MGI:1921269
See related
Ensembl:ENSMUSG00000034292 AllianceGenome:MGI:1921269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MIP-T3; 3930402D05Rik
Summary
Predicted to enable microtubule binding activity and signaling receptor binding activity. Involved in morphogenesis of a polarized epithelium and regulation of microtubule cytoskeleton organization. Acts upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in axoneme; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in genitourinary system and nose. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 7.5), CNS E11.5 (RPKM 5.8) and 28 other tissues See more
Orthologs
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Genomic context

See Traf3ip1 in Genome Data Viewer
Location:
1 D; 1 46.16 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91422311..91457029)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91494590..91529307)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28382 Neighboring gene nucleolar complex associated 3 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_01698 Neighboring gene STARR-positive B cell enhancer ABC_E1555 Neighboring gene ankyrin repeat and SOCS box-containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93497438-93497621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93498155-93498356 Neighboring gene predicted gene 28380

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC143957

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intraciliary anterograde transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intraciliary transport IC
Inferred by Curator
more info
PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in morphogenesis of a polarized epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in morphogenesis of a polarized epithelium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary tip ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium NAS
Non-traceable Author Statement
more info
PubMed 
located_in cilium TAS
Traceable Author Statement
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
PubMed 
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TRAF3-interacting protein 1
Names
TNF receptor-associated factor 3 interacting protein 1
intraflagellar transport protein 54 homolog
microtubule-interacting protein associated with TRAF3
microtubule-interacting protein that associates with TRAF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028718.2NP_082994.1  TRAF3-interacting protein 1

    See identical proteins and their annotated locations for NP_082994.1

    Status: VALIDATED

    Source sequence(s)
    AY613437, BC051115, BY739359, CK794620
    Consensus CDS
    CCDS35664.1
    UniProtKB/Swiss-Prot
    Q149C2, Q538H5, Q80VQ3, Q9CS98
    Related
    ENSMUSP00000042391.8, ENSMUST00000047242.9
    Conserved Domains (1) summary
    pfam10243
    Location:49619
    MIP-T3; Microtubule-binding protein MIP-T3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    91422311..91457029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153864.1XP_036009757.1  TRAF3-interacting protein 1 isoform X1

    Conserved Domains (3) summary
    PTZ00121
    Location:118392
    PTZ00121; MAEBL; Provisional
    pfam10243
    Location:5117
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam17749
    Location:552706
    MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
  2. XM_036153867.1XP_036009760.1  TRAF3-interacting protein 1 isoform X2

    Conserved Domains (3) summary
    PTZ00121
    Location:100362
    PTZ00121; MAEBL; Provisional
    pfam10243
    Location:5117
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam17749
    Location:528682
    MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
  3. XM_006529896.2XP_006529959.1  TRAF3-interacting protein 1 isoform X3

    Conserved Domains (3) summary
    PTZ00121
    Location:100672
    PTZ00121; MAEBL; Provisional
    pfam10243
    Location:5117
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam17749
    Location:518672
    MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
  4. XM_006529898.2XP_006529961.1  TRAF3-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A087WQD8
    Related
    ENSMUSP00000140151.2, ENSMUST00000189341.7
    Conserved Domains (3) summary
    PTZ00121
    Location:100648
    PTZ00121; MAEBL; Provisional
    pfam10243
    Location:5117
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam17749
    Location:494648
    MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region

RNA

  1. XR_004934797.1 RNA Sequence