Dnm1l dynamin 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnm1lprovided by MGI
Official Full Name: dynamin 1-likeprovided by MGI
Primary source: MGI:MGI:1921256
See related: Ensembl:ENSMUSG00000022789 AllianceGenome:MGI:1921256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlp1; Drp1; Dnmlp1; python; 6330417M19Rik
Summary: This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013]
Expression: Broad expression in cerebellum adult (RPKM 25.5), CNS E18 (RPKM 24.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16; 16 A2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (16130092..16176902, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (16312228..16359038, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.
Title: Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.
Title: CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.
Cystathionine gamma lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction.
Title: Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction.
AMPK/Drp1 pathway mediates Streptococcus uberis-Induced mitochondrial dysfunction.
Title: AMPK/Drp1 pathway mediates Streptococcus uberis-Induced mitochondrial dysfunction.
Mechanistic and therapeutic role of Drp1 in the pathogenesis of Alzheimer's disease.
Title: Mechanistic and therapeutic role of Drp1 in the pathogenesis of Alzheimer's disease.
Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals.
Title: Dynamin-Related Protein 1 Is Involved in Mitochondrial Damage, Defective Mitophagy, and NLRP3 Inflammasome Activation Induced by MSU Crystals.
Dynamin-related protein 1 differentially regulates FcepsilonRI- and substance P-induced mast cell activation.
Title: Dynamin-related protein 1 differentially regulates FcεRI- and substance P-induced mast cell activation.
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
Title: LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
Decreased mitophagy aggravates benign prostatic hyperplasia in aged mice through DRP1 and estrogen receptor alpha.
Title: Decreased mitophagy aggravates benign prostatic hyperplasia in aged mice through DRP1 and estrogen receptor α.
USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.
Title: USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.

Submit: New GeneRIF Correction See all GeneRIFs (199)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (7) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Dnm1l gene: The Dnm1l gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
Orthologs from Annotation Pipeline: 490 organisms have orthologs with human gene Dnm1l
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BH2 domain binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dynamin family protein polymerization involved in mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular distribution of mitochondria	ISO Inferred from Sequence Orthology more info
involved_in localization	ISO Inferred from Sequence Orthology more info
involved_in membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fragmentation involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mitochondrial fragmentation involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial membrane fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in peroxisome fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of ATP metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy of mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peroxisome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle recycling via endosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with clathrin-coated pit	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info	PubMed
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
colocalizes_with mitochondrion-derived vesicle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynamin-1-like protein

Names: dymple; dynamin family member proline-rich carboxyl-terminal domain less; dynamin-related protein 1

NP_001021118.1

EC 3.6.5.5

NP_001263269.1

EC 3.6.5.5

NP_001263270.1

EC 3.6.5.5

NP_001346936.1

EC 3.6.5.5

NP_001346937.1

EC 3.6.5.5

NP_001346938.1

EC 3.6.5.5

NP_001346939.1

EC 3.6.5.5

NP_690029.2

EC 3.6.5.5

XP_006522694.1

EC 3.6.5.5

XP_006522695.1

EC 3.6.5.5

XP_006522696.1

EC 3.6.5.5

XP_006522697.1

EC 3.6.5.5

XP_006522698.1

EC 3.6.5.5

XP_006522699.1

EC 3.6.5.5

XP_006522700.1

EC 3.6.5.5

XP_006522701.1

EC 3.6.5.5

XP_017172630.1

EC 3.6.5.5

XP_030105156.1

EC 3.6.5.5

XP_030105157.1

EC 3.6.5.5

XP_030105158.1

EC 3.6.5.5

XP_030105159.1

EC 3.6.5.5

XP_030105160.1

EC 3.6.5.5

XP_030105161.1

EC 3.6.5.5

XP_030105162.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025947.3 → NP_001021118.1 dynamin-1-like protein isoform b

See identical proteins and their annotated locations for NP_001021118.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (b) is shorter than isoform e.

Source sequence(s)

AC112943

Consensus CDS

CCDS27984.1

UniProtKB/Swiss-Prot

Q8K1M6

UniProtKB/TrEMBL

A0A8C6HF08

Related

ENSMUSP00000023477.8, ENSMUST00000023477.15

Conserved Domains (4) summary

cd08771
Location:23 → 302

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:88 → 692

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:227 → 510

Dynamin_M; Dynamin central region

pfam02212
Location:605 → 693

GED; Dynamin GTPase effector domain
NM_001276340.2 → NP_001263269.1 dynamin-1-like protein isoform c

See identical proteins and their annotated locations for NP_001263269.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (c) is shorter than isoform e.

Source sequence(s)

AC112943

Consensus CDS

CCDS70689.1

UniProtKB/Swiss-Prot

Q8K1M6

Related

ENSMUSP00000155155.2, ENSMUST00000230980.2

Conserved Domains (4) summary

cd08771
Location:23 → 308

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:94 → 709

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:233 → 516

Dynamin_M; Dynamin central region

pfam02212
Location:622 → 710

GED; Dynamin GTPase effector domain
NM_001276341.2 → NP_001263270.1 dynamin-1-like protein isoform d

See identical proteins and their annotated locations for NP_001263270.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate 5' structure, has multiple differences in the coding region and initiates translation at a downstream start codon, compared to variant 6. It encodes isoform d which has a shorter N-terminus compared to isoform e.

Source sequence(s)

AC112943

Consensus CDS

CCDS88885.1

UniProtKB/Swiss-Prot

Q8K1M6

UniProtKB/TrEMBL

A0A8C6HGB5

Related

ENSMUSP00000155429.2, ENSMUST00000230022.2

Conserved Domains (4) summary

cd08771
Location:3 → 204

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:1 → 605

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:129 → 412

Dynamin_M; Dynamin central region

pfam02212
Location:518 → 606

GED; Dynamin GTPase effector domain
NM_001360007.2 → NP_001346936.1 dynamin-1-like protein isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (e).

Source sequence(s)

AC112943

Conserved Domains (3) summary

cd08771
Location:23 → 321

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:245 → 528

Dynamin_M; Dynamin central region

pfam02212
Location:661 → 749

GED; Dynamin GTPase effector domain
NM_001360008.2 → NP_001346937.1 dynamin-1-like protein isoform f

Status: REVIEWED

Description

Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (f) is shorter than isoform e.

Source sequence(s)

AC112943

UniProtKB/TrEMBL

A0A8C6HFR3

Conserved Domains (3) summary

cd08771
Location:23 → 315

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:239 → 522

Dynamin_M; Dynamin central region

pfam02212
Location:655 → 743

GED; Dynamin GTPase effector domain
NM_001360009.2 → NP_001346938.1 dynamin-1-like protein isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (g) is shorter than isoform e.

Source sequence(s)

AC112943

Conserved Domains (3) summary

cd08771
Location:23 → 321

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:245 → 528

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 738

GED; Dynamin GTPase effector domain
NM_001360010.2 → NP_001346939.1 dynamin-1-like protein isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (h) is shorter than isoform e.

Source sequence(s)

AC112943

Conserved Domains (3) summary

cd08771
Location:23 → 315

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:239 → 522

Dynamin_M; Dynamin central region

pfam02212
Location:629 → 717

GED; Dynamin GTPase effector domain
NM_001405252.1 → NP_001392181.1 dynamin-1-like protein isoform d

Status: REVIEWED

Source sequence(s)

AC112943

UniProtKB/TrEMBL

A0A8C6HGB5
NM_001405253.1 → NP_001392182.1 dynamin-1-like protein isoform i

Status: REVIEWED

Source sequence(s)

AC112943

UniProtKB/Swiss-Prot

Q8K1A1
NM_001405254.1 → NP_001392183.1 dynamin-1-like protein isoform j

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405255.1 → NP_001392184.1 dynamin-1-like protein isoform k

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405256.1 → NP_001392185.1 dynamin-1-like protein isoform l

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405257.1 → NP_001392186.1 dynamin-1-like protein isoform m

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405258.1 → NP_001392187.1 dynamin-1-like protein isoform n

Status: REVIEWED

Source sequence(s)

AC112943

UniProtKB/TrEMBL

A0A8C6HFT9
NM_001405259.1 → NP_001392188.1 dynamin-1-like protein isoform o

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405260.1 → NP_001392189.1 dynamin-1-like protein isoform p

Status: REVIEWED

Source sequence(s)

AC112943

UniProtKB/TrEMBL

A0A8C6HE39
NM_001405261.1 → NP_001392190.1 dynamin-1-like protein isoform q

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405262.1 → NP_001392191.1 dynamin-1-like protein isoform r

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405263.1 → NP_001392192.1 dynamin-1-like protein isoform s

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405264.1 → NP_001392193.1 dynamin-1-like protein isoform t

Status: REVIEWED

Source sequence(s)

AC112943
NM_001405265.1 → NP_001392194.1 dynamin-1-like protein isoform t

Status: REVIEWED

Source sequence(s)

AC112943
NM_152816.4 → NP_690029.2 dynamin-1-like protein isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (a) is shorter than isoform e.

Source sequence(s)

AC112943

Consensus CDS

CCDS27985.1

UniProtKB/Swiss-Prot

Q8K1M6

UniProtKB/TrEMBL

E9PUD2

Related

ENSMUSP00000093945.4, ENSMUST00000096229.11

Conserved Domains (4) summary

cd08771
Location:23 → 315

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:101 → 705

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:240 → 523

Dynamin_M; Dynamin central region

pfam02212
Location:618 → 706

GED; Dynamin GTPase effector domain

RNA

NR_075074.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences, compared to variant 6. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC112943
NR_175921.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175922.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175923.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175924.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175925.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175926.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175927.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175928.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175929.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175930.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175931.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175932.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943
NR_175933.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112943

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

16130092..16176902 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522635.4 → XP_006522698.1 dynamin-1-like protein isoform X6

Conserved Domains (3) summary

cd08771
Location:23 → 302

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:226 → 510

Dynamin_M; Dynamin central region

pfam02212
Location:630 → 719

GED; Dynamin GTPase effector domain
XM_006522633.3 → XP_006522696.1 dynamin-1-like protein isoform X3

Conserved Domains (3) summary

cd08771
Location:23 → 302

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:226 → 510

Dynamin_M; Dynamin central region

pfam02212
Location:641 → 730

GED; Dynamin GTPase effector domain
XM_006522632.4 → XP_006522695.1 dynamin-1-like protein isoform X2

Conserved Domains (3) summary

cd08771
Location:23 → 315

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:239 → 523

Dynamin_M; Dynamin central region

pfam02212
Location:643 → 732

GED; Dynamin GTPase effector domain
XM_030249296.1 → XP_030105156.1 dynamin-1-like protein isoform X4

Conserved Domains (3) summary

cd08771
Location:23 → 308

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:232 → 516

Dynamin_M; Dynamin central region

pfam02212
Location:636 → 725

GED; Dynamin GTPase effector domain
XM_006522631.4 → XP_006522694.1 dynamin-1-like protein isoform X1

UniProtKB/Swiss-Prot

Q8K1M6

Conserved Domains (3) summary

cd08771
Location:23 → 308

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:232 → 516

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 736

GED; Dynamin GTPase effector domain
XM_006522636.3 → XP_006522699.1 dynamin-1-like protein isoform X7

Conserved Domains (3) summary

cd08771
Location:23 → 321

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:245 → 529

Dynamin_M; Dynamin central region

pfam02212
Location:623 → 712

GED; Dynamin GTPase effector domain
XM_006522634.3 → XP_006522697.1 dynamin-1-like protein isoform X5

Conserved Domains (3) summary

cd08771
Location:23 → 321

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:245 → 529

Dynamin_M; Dynamin central region

pfam02212
Location:634 → 723

GED; Dynamin GTPase effector domain
XM_006522637.4 → XP_006522700.1 dynamin-1-like protein isoform X8

Conserved Domains (3) summary

cd08771
Location:23 → 302

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:226 → 510

Dynamin_M; Dynamin central region

pfam02212
Location:615 → 704

GED; Dynamin GTPase effector domain
XM_030249299.2 → XP_030105159.1 dynamin-1-like protein isoform X11

Conserved Domains (3) summary

pfam01031
Location:36 → 320

Dynamin_M; Dynamin central region

pfam02212
Location:451 → 540

GED; Dynamin GTPase effector domain

cl38985
Location:1 → 65

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_017317141.3 → XP_017172630.1 dynamin-1-like protein isoform X13

Conserved Domains (2) summary

pfam01031
Location:46 → 217

Dynamin_M; Dynamin central region

pfam02212
Location:337 → 426

GED; Dynamin GTPase effector domain
XM_030249300.2 → XP_030105160.1 dynamin-1-like protein isoform X12

Conserved Domains (2) summary

pfam01031
Location:46 → 217

Dynamin_M; Dynamin central region

pfam02212
Location:348 → 437

GED; Dynamin GTPase effector domain
XM_030249301.2 → XP_030105161.1 dynamin-1-like protein isoform X12

Conserved Domains (2) summary

pfam01031
Location:46 → 217

Dynamin_M; Dynamin central region

pfam02212
Location:348 → 437

GED; Dynamin GTPase effector domain
XM_030249297.2 → XP_030105157.1 dynamin-1-like protein isoform X9

Related

ENSMUSP00000111415.3, ENSMUST00000115749.3

Conserved Domains (3) summary

cd08771
Location:1 → 153

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:77 → 361

Dynamin_M; Dynamin central region

pfam02212
Location:492 → 581

GED; Dynamin GTPase effector domain
XM_006522638.5 → XP_006522701.1 dynamin-1-like protein isoform X9

UniProtKB/TrEMBL

A0A2U3TZ67

Conserved Domains (3) summary

cd08771
Location:1 → 153

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:77 → 361

Dynamin_M; Dynamin central region

pfam02212
Location:492 → 581

GED; Dynamin GTPase effector domain
XM_030249298.2 → XP_030105158.1 dynamin-1-like protein isoform X10

Conserved Domains (3) summary

cd08771
Location:1 → 153

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:77 → 361

Dynamin_M; Dynamin central region

pfam02212
Location:455 → 544

GED; Dynamin GTPase effector domain
XM_030249302.1 → XP_030105162.1 dynamin-1-like protein isoform X14

Conserved Domains (2) summary

pfam01031
Location:46 → 217

Dynamin_M; Dynamin central region

pfam02212
Location:322 → 411

GED; Dynamin GTPase effector domain