Arhgap18 Rho GTPase activating protein 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap18provided by MGI
Official Full Name: Rho GTPase activating protein 18provided by MGI
Primary source: MGI:MGI:1921160
See related: Ensembl:ENSMUSG00000039031 AllianceGenome:MGI:1921160
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4833419J07Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including regulation of actin filament polymerization; regulation of small GTPase mediated signal transduction; and small GTPase mediated signal transduction. Predicted to be located in several cellular components, including cytoplasmic microtubule; nuclear speck; and ruffle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human ARHGAP18 (Rho GTPase activating protein 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 9.0), bladder adult (RPKM 3.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 A4

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (26648363..26794644)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (26772408..26918648)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment.
Title: YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment.
mechanical activation of RhoA in mesenchymal progenitors is dependent on LARG, while ARHGAP18 limits RhoA delineated cytoskeletal structure in static cultures
Title: LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage.
ARHGAP 18 was identified as a novel protective gene against thoracic aortic aneurysm formation.
Title: ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype.
In endothelial cells, ARHGAP18 may act as a significant regulator of vascular homeostasis.
Title: The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.
Results describe ARHGAP18 as a novel negative regulator of sprouting by acting dualistically to limit tip cell formation and to maintain junctional integrity.
Title: ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236322

AI843501 (e-PCR)
- UniSTS:165683

AI314906 (e-PCR)
- UniSTS:185820

Homology

Homologs of the Arhgap18 gene: The Arhgap18 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 493 organisms have orthologs with human gene Arhgap18
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 18

Names: rho-type GTPase-activating protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176837.2 → NP_789807.1 rho GTPase-activating protein 18

See identical proteins and their annotated locations for NP_789807.1

Status: PROVISIONAL

Source sequence(s)

AC101709, AC158631

Consensus CDS

CCDS23757.1

UniProtKB/Swiss-Prot

Q8K0Q5, Q8R196

Related

ENSMUSP00000044834.8, ENSMUST00000039557.9

Conserved Domains (1) summary

cd04391
Location:321 → 534

RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

26648363..26794644

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512885.5 → XP_006512948.1 rho GTPase-activating protein 18 isoform X1

Conserved Domains (1) summary

cd04391
Location:321 → 534

RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...