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Arhgap18 Rho GTPase activating protein 18 [ Mus musculus (house mouse) ]

Gene ID: 73910, updated on 21-Apr-2024

Summary

Official Symbol
Arhgap18provided by MGI
Official Full Name
Rho GTPase activating protein 18provided by MGI
Primary source
MGI:MGI:1921160
See related
Ensembl:ENSMUSG00000039031 AllianceGenome:MGI:1921160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833419J07Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including regulation of actin filament polymerization; regulation of small GTPase mediated signal transduction; and small GTPase mediated signal transduction. Predicted to be located in several cellular components, including cytoplasmic microtubule; nuclear speck; and ruffle. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human ARHGAP18 (Rho GTPase activating protein 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 9.0), bladder adult (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

Location:
10 A4; 10 14.12 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (26648363..26794644)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (26772408..26918648)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 48893 Neighboring gene STARR-seq mESC enhancer starr_26133 Neighboring gene STARR-seq mESC enhancer starr_26134 Neighboring gene STARR-seq mESC enhancer starr_26135 Neighboring gene STARR-seq mESC enhancer starr_26136 Neighboring gene STARR-seq mESC enhancer starr_26137 Neighboring gene STARR-seq mESC enhancer starr_26138 Neighboring gene STARR-seq mESC enhancer starr_26139 Neighboring gene STARR-seq mESC enhancer starr_26140 Neighboring gene STARR-seq mESC enhancer starr_26141 Neighboring gene predicted gene, 30534 Neighboring gene predicted gene, 40618 Neighboring gene laminin, alpha 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 18
Names
rho-type GTPase-activating protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176837.2NP_789807.1  rho GTPase-activating protein 18

    See identical proteins and their annotated locations for NP_789807.1

    Status: PROVISIONAL

    Source sequence(s)
    AC101709, AC158631
    Consensus CDS
    CCDS23757.1
    UniProtKB/Swiss-Prot
    Q8BP03, Q8K0Q5, Q8R196
    UniProtKB/TrEMBL
    A0A2X0SYS9
    Related
    ENSMUSP00000044834.8, ENSMUST00000039557.9
    Conserved Domains (1) summary
    cd04391
    Location:321534
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    26648363..26794644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512885.5XP_006512948.1  rho GTPase-activating protein 18 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SYS9
    Conserved Domains (1) summary
    cd04391
    Location:321534
    RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

RNA

  1. XR_001779622.3 RNA Sequence