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UPK2 uroplakin 2 [ Homo sapiens (human) ]

Gene ID: 7379, updated on 1-Aug-2020

Summary

Official Symbol
UPK2provided by HGNC
Official Full Name
uroplakin 2provided by HGNC
Primary source
HGNC:HGNC:12579
See related
Ensembl:ENSG00000110375 MIM:611558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UP2; UPII
Summary
This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
Expression
Biased expression in urinary bladder (RPKM 26.3) and fat (RPKM 1.3) See more
Orthologs

Genomic context

See UPK2 in Genome Data Viewer
Location:
11q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118956298..118958559)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118827008..118829269)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BCL9 like Neighboring gene microRNA 4492 Neighboring gene RNA, 7SL, cytoplasmic 688, pseudogene Neighboring gene forkhead box R1 Neighboring gene CENATAC divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138598

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
uroplakin-2
Names
uroplakin II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006760.4NP_006751.1  uroplakin-2 precursor

    See identical proteins and their annotated locations for NP_006751.1

    Status: REVIEWED

    Source sequence(s)
    CD556028, Y13645
    Consensus CDS
    CCDS8404.1
    UniProtKB/Swiss-Prot
    O00526
    Related
    ENSP00000264031.2, ENST00000264031.3
    Conserved Domains (1) summary
    cl06408
    Location:24184
    UP_III_II; Uroplakin IIIb, IIIa and II

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118956298..118958559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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