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Tubb2b tubulin, beta 2B class IIB [ Mus musculus (house mouse) ]

Gene ID: 73710, updated on 18-Apr-2024

Summary

Official Symbol
Tubb2bprovided by MGI
Official Full Name
tubulin, beta 2B class IIBprovided by MGI
Primary source
MGI:MGI:1920960
See related
Ensembl:ENSMUSG00000045136 AllianceGenome:MGI:1920960
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
brdp; 2410129E14Rik
Summary
Predicted to enable GTP binding activity and protein heterodimerization activity. Predicted to be a structural constituent of cytoskeleton. Involved in modulation of chemical synaptic transmission. Acts upstream of or within embryonic brain development. Located in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; large intestine; lung; sensory organ; and thymus. Used to study complex cortical dysplasia with other brain malformations 7. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 7. Orthologous to human TUBB2B (tubulin beta 2B class IIb). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 3958.4), whole brain E14.5 (RPKM 3057.3) and 4 other tissues See more
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Genomic context

Location:
13 A3.3; 13 14.04 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34310991..34314337, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34127008..34130354, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene tubulin, beta 2A class IIA Neighboring gene RIKEN cDNA 4930447K03 gene Neighboring gene STARR-seq mESC enhancer starr_34135 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:34211307-34211509 Neighboring gene STARR-seq mESC enhancer starr_34137 Neighboring gene predicted gene, 36500 Neighboring gene VISTA enhancer mm1605 Neighboring gene predicted gene, 36549

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon guidance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023716.2NP_076205.1  tubulin beta-2B chain

    See identical proteins and their annotated locations for NP_076205.1

    Status: PROVISIONAL

    Source sequence(s)
    AK010786
    Consensus CDS
    CCDS26445.1
    UniProtKB/Swiss-Prot
    Q3TG26, Q9CWF2
    UniProtKB/TrEMBL
    B2RSN3, Q3U9U3
    Related
    ENSMUSP00000075178.4, ENSMUST00000075774.5
    Conserved Domains (1) summary
    PLN00220
    Location:1430
    PLN00220; tubulin beta chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    34310991..34314337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)