Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufaf7provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase complex assembly factor 7provided by MGI
Primary source: MGI:MGI:1920944
See related: Ensembl:ENSMUSG00000024082 AllianceGenome:MGI:1920944
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PRO1853; 2410091C18Rik
Summary: Predicted to enable enzyme binding activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine methylation, to symmetrical-dimethyl arginine. Predicted to act upstream of or within methylation. Located in mitochondrion. Is expressed in brain. Orthologous to human NDUFAF7 (NADH:ubiquinone oxidoreductase complex assembly factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 7.7), cortex adult (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 E3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (79244535..79255481)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (78937106..78948052)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NDUFAF7 functions to methylate NDUFS2 after it assembles into a complex I, stabilizing an early intermediate in the assembly pathway, and that this function is essential for normal vertebrate development.
Title: The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488884

RH124184 (e-PCR)
- UniSTS:161006

Homology

Homologs of the Ndufaf7 gene: The Ndufaf7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 502 organisms have orthologs with human gene Ndufaf7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N symmetric methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein-arginine omega-N symmetric methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-arginine methylation, to symmetrical-dimethyl arginine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein arginine methyltransferase NDUFAF7, mitochondrial

Names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex assembly factor 7; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7; protein midA homolog, mitochondrial

NP_082887.2

EC 2.1.1.320

XP_006525058.1

EC 2.1.1.320

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028611.3 → NP_082887.2 protein arginine methyltransferase NDUFAF7, mitochondrial precursor

See identical proteins and their annotated locations for NP_082887.2

Status: VALIDATED

Source sequence(s)

AC154274, AK010752, CF617214, CX236822

Consensus CDS

CCDS28982.1

UniProtKB/Swiss-Prot

Q8C1X3, Q9CWG8

Related

ENSMUSP00000024887.5, ENSMUST00000024887.6

Conserved Domains (2) summary

COG1565
Location:46 → 402

MidA; SAM-dependent methyltransferase, MidA family [General function prediction only]

pfam02636
Location:95 → 349

Methyltransf_28; Putative S-adenosyl-L-methionine-dependent methyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

79244535..79255481

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524995.2 → XP_006525058.1 protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1

Conserved Domains (1) summary

cl17173
Location:46 → 354

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

XR_385374.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_144760.1: Suppressed sequence

Description

NM_144760.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.