Format

Send to:

Choose Destination

UGT2B17 UDP glucuronosyltransferase family 2 member B17 [ Homo sapiens (human) ]

Gene ID: 7367, updated on 11-Jun-2021

Summary

Official Symbol
UGT2B17provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member B17provided by HGNC
Primary source
HGNC:HGNC:12547
See related
Ensembl:ENSG00000197888 MIM:601903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMND12; UDPGT2B17
Summary
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]
Expression
Biased expression in small intestine (RPKM 270.0), colon (RPKM 223.4) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See UGT2B17 in Genome Data Viewer
Location:
4q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (68537173..68576322, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69402891..69442040, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 11E Neighboring gene UDP glucuronosyltransferase family 2 member B29, pseudogene Neighboring gene RAS guanyl releasing protein 2 (calcium and DAG-regulated) pseudogene Neighboring gene UBX domain protein 2A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in estrogen metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in steroid metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
UDP-glucuronosyltransferase 2B17
Names
C19-steroid-specific UDP-glucuronosyltransferase
C19-steroid-specific UDPGT
UDP glucuronosyltransferase 2 family, polypeptide B17
UDP glycosyltransferase 2 family, member B17
UDP-glucuronyltransferase, family 2, beta-17
NP_001068.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017033.1 RefSeqGene

    Range
    5001..36344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077.4NP_001068.1  UDP-glucuronosyltransferase 2B17 precursor

    See identical proteins and their annotated locations for NP_001068.1

    Status: REVIEWED

    Source sequence(s)
    AC134921, AC147055
    Consensus CDS
    CCDS3523.1
    UniProtKB/Swiss-Prot
    O75795
    Related
    ENSP00000320401.2, ENST00000317746.3
    Conserved Domains (1) summary
    pfam00201
    Location:24518
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    68537173..68576322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center