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UGT2B15 UDP glucuronosyltransferase family 2 member B15 [ Homo sapiens (human) ]

Gene ID: 7366, updated on 21-Dec-2019

Summary

Official Symbol
UGT2B15provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member B15provided by HGNC
Primary source
HGNC:HGNC:12546
See related
Ensembl:ENSG00000196620 MIM:600069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLUG4; UGT2B8; UDPGTH3; UDPGT 2B8; UDPGT2B15
Summary
This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4. [provided by RefSeq, Aug 2016]
Expression
Biased expression in liver (RPKM 181.3), gall bladder (RPKM 125.4) and 4 other tissues See more
Orthologs

Genomic context

See UGT2B15 in Genome Data Viewer
Location:
4q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (68646597..68670652, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69512315..69536494, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UBX domain protein 2A pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B15 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B15 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
steroid metabolic process TAS
Traceable Author Statement
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UDP-glucuronosyltransferase 2B15
Names
UDP glucuronosyltransferase 2 family, member 15
UDP glucuronosyltransferase 2 family, member B8
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glycosyltransferase 2B15
UDP gycosyltransferase 2 family, member B15
UDP-glucuronosyltransferase 2B8
UDP-glucuronosyltransferase UGT2B15
UDP-glucuronyltransferase, family 2, beta-15
uridine diphosphate glucuronosyltransferase 2 family, member B8
uridine diphosphate glycosyltransferase 2 family, member B15
NP_001067.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052676.1 RefSeqGene

    Range
    5125..29180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001076.4NP_001067.2  UDP-glucuronosyltransferase 2B15 precursor

    See identical proteins and their annotated locations for NP_001067.2

    Status: REVIEWED

    Source sequence(s)
    AC147055, AF180322, U06641
    Consensus CDS
    CCDS3524.1
    UniProtKB/Swiss-Prot
    P54855
    Related
    ENSP00000341045.5, ENST00000338206.6
    Conserved Domains (2) summary
    PHA03392
    Location:8508
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:24518
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    68646597..68670652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167250.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    222964..247007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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