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UGT2B10 UDP glucuronosyltransferase family 2 member B10 [ Homo sapiens (human) ]

Gene ID: 7365, updated on 10-Jan-2019

Summary

Official Symbol
UGT2B10provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member B10provided by HGNC
Primary source
HGNC:HGNC:12544
See related
Ensembl:ENSG00000109181 MIM:600070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UDPGT2B10
Expression
Restricted expression toward liver (RPKM 194.6) See more

Genomic context

See UGT2B10 in Genome Data Viewer
Location:
4q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (68815993..68832038)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69681713..69697741)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B17 pseudogene Neighboring gene UDP-glucuronosyltransferase 2B10-like Neighboring gene speckle type BTB/POZ protein like pseudogene Neighboring gene UDP-glucuronosyltransferase 2B10-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142209

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UDP-glucuronosyltransferase 2B10
Names
UDP glucuronosyltransferase 2 family, polypeptide B10
UDPGT 2B10
NP_001066.1
NP_001138239.1
NP_001277020.1
XP_016864074.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075.6NP_001066.1  UDP-glucuronosyltransferase 2B10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021146, AK292738, BC113649
    Consensus CDS
    CCDS75136.1
    UniProtKB/Swiss-Prot
    P36537
    Related
    ENSP00000265403.7, ENST00000265403.11
    Conserved Domains (1) summary
    pfam00201
    Location:23524
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  2. NM_001144767.2NP_001138239.1  UDP-glucuronosyltransferase 2B10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001138239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC021146, AK298432, BC113649
    Consensus CDS
    CCDS75135.1
    UniProtKB/Swiss-Prot
    P36537
    Related
    ENSP00000413420.2, ENST00000458688.2
    Conserved Domains (3) summary
    PHA03392
    Location:184422
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:23440
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl21454
    Location:3982
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001290091.1NP_001277020.1  UDP-glucuronosyltransferase 2B10 isoform 3

    See identical proteins and their annotated locations for NP_001277020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC021146, BC113649, CD013994
    UniProtKB/Swiss-Prot
    P36537
    Conserved Domains (2) summary
    PHA03392
    Location:20258
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:1276
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    68815993..68832038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008585.2XP_016864074.1  UDP-glucuronosyltransferase 2B10 isoform X1

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_167250.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    392012..408036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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