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UGT2B4 UDP glucuronosyltransferase family 2 member B4 [ Homo sapiens (human) ]

Gene ID: 7363, updated on 11-Sep-2019

Summary

Official Symbol
UGT2B4provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member B4provided by HGNC
Primary source
HGNC:HGNC:12553
See related
Ensembl:ENSG00000156096 MIM:600067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLUG25; UDPGTH1; UGT2B11; UDPGT2B4; UDPGTh-1
Expression
Restricted expression toward liver (RPKM 259.3) See more
Orthologs

Genomic context

See UGT2B4 in Genome Data Viewer
Location:
4q13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (69480165..69526014, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70345883..70391732, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B24, pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene 7 Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A2 Neighboring gene UDP glucuronosyltransferase family 2 member A1 complex locus

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UDP-glucuronosyltransferase 2B4
Names
UDP glucuronosyltransferase 2 family, polypeptide B4
UDP-glucuronyltransferase, family 2, beta-4
UDPGT 2B4
hyodeoxycholic acid
hyodeoxycholic acid-specific UDPGT
NP_001284544.1
NP_001284545.1
NP_066962.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297615.2NP_001284544.1  UDP-glucuronosyltransferase 2B4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001284544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF064200, AJ005162, AY529122, BX494777
    Consensus CDS
    CCDS75137.1
    UniProtKB/Swiss-Prot
    P06133
    Related
    ENSP00000421290.1, ENST00000512583.5
    Conserved Domains (2) summary
    pfam00201
    Location:24363
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl10013
    Location:8368
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
  2. NM_001297616.1NP_001284545.1  UDP-glucuronosyltransferase 2B4 isoform 3

    See identical proteins and their annotated locations for NP_001284545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF064200, AK300084
    UniProtKB/Swiss-Prot
    P06133
    Conserved Domains (2) summary
    PHA03392
    Location:133376
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:15388
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  3. NM_021139.3NP_066962.2  UDP-glucuronosyltransferase 2B4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_066962.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF064200, BC026264, Y00317
    Consensus CDS
    CCDS43234.1
    UniProtKB/Swiss-Prot
    P06133
    Related
    ENSP00000305221.6, ENST00000305107.7
    Conserved Domains (2) summary
    PHA03392
    Location:8512
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:24524
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    69480165..69526014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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