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Izumo1 izumo sperm-egg fusion 1 [ Mus musculus (house mouse) ]

Gene ID: 73456, updated on 12-May-2024

Summary

Official Symbol
Izumo1provided by MGI
Official Full Name
izumo sperm-egg fusion 1provided by MGI
Primary source
MGI:MGI:1920706
See related
Ensembl:ENSMUSG00000064158 AllianceGenome:MGI:1920706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Izumo; 1700058F15Rik
Summary
Enables protein binding activity involved in heterotypic cell-cell adhesion; protein homodimerization activity; and signaling receptor binding activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization; heterotypic cell-cell adhesion; and sperm-egg recognition. Located in acrosomal membrane and plasma membrane. Is integral component of membrane. Orthologous to human IZUMO1 (izumo sperm-egg fusion 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 34.7) See more
Orthologs
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Genomic context

See Izumo1 in Genome Data Viewer
Location:
7 B3; 7 29.39 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45270251..45276653)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45621811..45627242)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31479 Neighboring gene Fgf21 promoter region Neighboring gene fibroblast growth factor 21 Neighboring gene fucosyltransferase 1 Neighboring gene Ras interacting protein 1 Neighboring gene RIKEN cDNA A030001D20 gene Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene STARR-positive B cell enhancer mm9_chr7:52899034-52899335

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding involved in heterotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding involved in heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding involved in heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in acrosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein complex involved in cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
izumo sperm-egg fusion protein 1
Names
OBF
oocyte binding/fusion factor
sperm-specific protein Izumo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018013.2NP_001018013.1  izumo sperm-egg fusion protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001018013.1

    Status: VALIDATED

    Source sequence(s)
    AC149057
    Consensus CDS
    CCDS21255.1
    UniProtKB/Swiss-Prot
    Q9D9J7
    Related
    ENSMUSP00000033100.5, ENSMUST00000033100.5
    Conserved Domains (2) summary
    pfam15005
    Location:22165
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated
    pfam16706
    Location:170255
    Izumo-Ig; Izumo-like Immunoglobulin domain
  2. NM_001418984.1NP_001405913.1  izumo sperm-egg fusion protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149057
    UniProtKB/TrEMBL
    A0A455R725
  3. NM_001418985.1NP_001405914.1  izumo sperm-egg fusion protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC149057
  4. NM_001418986.1NP_001405915.1  izumo sperm-egg fusion protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC149057
    UniProtKB/Swiss-Prot
    Q9D9J7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45270251..45276653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153471.1XP_036009364.1  izumo sperm-egg fusion protein 1 isoform X3

    Conserved Domains (2) summary
    pfam15005
    Location:53196
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated
    pfam16706
    Location:201282
    Izumo-Ig; Izumo-like Immunoglobulin domain
  2. XM_036153472.1XP_036009365.1  izumo sperm-egg fusion protein 1 isoform X4

    Conserved Domains (2) summary
    pfam15005
    Location:53196
    IZUMO; Izumo sperm-egg fusion, Ig domain-associated
    pfam16706
    Location:201282
    Izumo-Ig; Izumo-like Immunoglobulin domain