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Dcbld2 discoidin, CUB and LCCL domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 73379, updated on 8-Feb-2024

Summary

Official Symbol
Dcbld2provided by MGI
Official Full Name
discoidin, CUB and LCCL domain containing 2provided by MGI
Primary source
MGI:MGI:1920629
See related
Ensembl:ENSMUSG00000035107 AllianceGenome:MGI:1920629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Esdn; CLCP1; 1700055P21Rik
Summary
Predicted to be involved in negative regulation of cell growth and wound healing. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Orthologous to human DCBLD2 (discoidin, CUB and LCCL domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.6), CNS E11.5 (RPKM 10.5) and 27 other tissues See more
Orthologs
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Genomic context

See Dcbld2 in Genome Data Viewer
Location:
16 C1.2; 16 34.52 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58228789..58304013)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58408535..58469745)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57639 Neighboring gene STARR-seq mESC enhancer starr_41093 Neighboring gene predicted gene, 41463 Neighboring gene STARR-seq mESC enhancer starr_41094 Neighboring gene STARR-seq mESC enhancer starr_41095 Neighboring gene RIKEN cDNA 4930461C15 gene Neighboring gene STARR-positive B cell enhancer ABC_E1928 Neighboring gene STARR-seq mESC enhancer starr_41096 Neighboring gene STARR-positive B cell enhancer ABC_E3167 Neighboring gene STARR-positive B cell enhancer ABC_E8639 Neighboring gene STARR-positive B cell enhancer ABC_E3168 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Neighboring gene STARR-seq mESC enhancer starr_41097 Neighboring gene STARR-seq mESC enhancer starr_41098 Neighboring gene predicted gene, 20942 Neighboring gene ferritin domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
discoidin, CUB and LCCL domain-containing protein 2
Names
endothelial and smooth muscle cell-derived neuropilin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356484.1NP_001343413.1  discoidin, CUB and LCCL domain-containing protein 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT027564
    Conserved Domains (3) summary
    cd00041
    Location:69183
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:293445
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:190272
    LCCL; LCCL domain
  2. NM_028523.3NP_082799.2  discoidin, CUB and LCCL domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_082799.2

    Status: VALIDATED

    Source sequence(s)
    AK043915, AK051889, AK052189, BC066097, CAAA01184608
    Consensus CDS
    CCDS28229.1
    UniProtKB/Swiss-Prot
    A6X950, Q8BKI4, Q91ZV3
    Related
    ENSMUSP00000039915.8, ENSMUST00000046663.8
    Conserved Domains (4) summary
    smart00231
    Location:288446
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:69183
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:293445
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:190272
    LCCL; LCCL domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    58228789..58304013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160148.1XP_036016041.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    cd00041
    Location:69183
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl25480
    Location:293400
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:190272
    LCCL; LCCL domain
  2. XM_036160149.1XP_036016042.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    cd00041
    Location:69183
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl25480
    Location:293400
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl02694
    Location:190272
    LCCL; LCCL domain
  3. XM_011246022.3XP_011244324.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X3

    Conserved Domains (3) summary
    cd00057
    Location:217369
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl00049
    Location:66107
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl02694
    Location:114196
    LCCL; LCCL domain

RNA

  1. XR_004939243.1 RNA Sequence

  2. XR_004939244.1 RNA Sequence

  3. XR_004939245.1 RNA Sequence

  4. XR_004939246.1 RNA Sequence

  5. XR_004939247.1 RNA Sequence

  6. XR_004939248.1 RNA Sequence