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UBE2V2 ubiquitin conjugating enzyme E2 V2 [ Homo sapiens (human) ]

Gene ID: 7336, updated on 13-Mar-2020

Summary

Official Symbol
UBE2V2provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 V2provided by HGNC
Primary source
HGNC:HGNC:12495
See related
Ensembl:ENSG00000169139 MIM:603001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1
Summary
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 22.2), adrenal (RPKM 12.6) and 25 other tissues See more
Orthologs

Genomic context

See UBE2V2 in Genome Data Viewer
Location:
8q11.21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (47997527..48064708)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (48920966..48977268)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized TCONS_00068220 Neighboring gene minichromosome maintenance complex component 4 Neighboring gene RNA, U6 small nuclear 519, pseudogene Neighboring gene uncharacterized LOC107986941 Neighboring gene cell division cycle associated 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 
error-free postreplication DNA repair IEA
Inferred from Electronic Annotation
more info
 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination TAS
Traceable Author Statement
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
PubMed 
regulation of DNA repair TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
UBC13-MMS2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 variant 2
Names
1 alpha,25-dihydroxyvitamin D3-inducible
DDVit 1
MMS2 homolog
enterocyte differentiation promoting factor
enterocyte differentiation-associated factor 1
enterocyte differentiation-associated factor EDAF-1
enterocyte differentiation-promoting factor 1
methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
vitamin D3-inducible protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003350.3NP_003341.1  ubiquitin-conjugating enzyme E2 variant 2

    See identical proteins and their annotated locations for NP_003341.1

    Status: REVIEWED

    Source sequence(s)
    AC021236
    Consensus CDS
    CCDS43738.1
    UniProtKB/Swiss-Prot
    Q15819
    UniProtKB/TrEMBL
    A0M8W4
    Related
    ENSP00000428209.1, ENST00000523111.7
    Conserved Domains (1) summary
    smart00212
    Location:14145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    47997527..48064708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013808.2XP_016869297.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X2

  2. XM_011517583.3XP_011515885.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X1

    Conserved Domains (1) summary
    smart00212
    Location:42173
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
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