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Ccdc103 coiled-coil domain containing 103 [ Mus musculus (house mouse) ]

Gene ID: 73293, updated on 5-Mar-2024

Summary

Official Symbol
Ccdc103provided by MGI
Official Full Name
coiled-coil domain containing 103provided by MGI
Primary source
MGI:MGI:1920543
See related
Ensembl:ENSMUSG00000020930 AllianceGenome:MGI:1920543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700039D13Rik
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in axonemal dynein complex assembly; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Predicted to act upstream of or within cell projection organization. Predicted to be located in cytoplasm and motile cilium. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 17. Orthologous to human CCDC103 (coiled-coil domain containing 103). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 8.7), cortex adult (RPKM 0.7) and 3 other tissues See more
Orthologs
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Genomic context

See Ccdc103 in Genome Data Viewer
Location:
11 E1; 11 66.48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102772050..102776042)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102881224..102885216)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene HIG1 domain family, member 1B Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102742482-102742665 Neighboring gene family with sequence similarity 187, member A Neighboring gene glial fibrillary acidic protein Neighboring gene predicted gene, 34560 Neighboring gene kinesin family member 18B Neighboring gene STARR-seq mESC enhancer starr_30821

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
 
involved_in determination of digestive tract left/right asymmetry ISO
Inferred from Sequence Orthology
more info
 
involved_in determination of left/right symmetry IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epithelial cilium movement involved in extracellular fluid movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heart looping ISO
Inferred from Sequence Orthology
more info
 
involved_in inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
part_of outer dynein arm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 103

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364757.1NP_001351686.1  coiled-coil domain-containing protein 103 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL731670
    Conserved Domains (1) summary
    pfam13877
    Location:30118
    RPAP3_C; Potential Monad-binding region of RPAP3
  2. NM_028492.3NP_082768.1  coiled-coil domain-containing protein 103 isoform 1

    See identical proteins and their annotated locations for NP_082768.1

    Status: VALIDATED

    Source sequence(s)
    AI836178, AK032002, AL731670
    Consensus CDS
    CCDS25506.1
    UniProtKB/Swiss-Prot
    A2AH86, Q9D9P2
    Related
    ENSMUSP00000021307.4, ENSMUST00000021307.10
    Conserved Domains (2) summary
    pfam13877
    Location:98188
    RPAP3_C; Potential Monad-binding region of RPAP3
    pfam15867
    Location:774
    Dynein_attach_N; Dynein attachment factor N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102772050..102776042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)