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Pear1 platelet endothelial aggregation receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 73182, updated on 11-Apr-2024

Summary

Official Symbol
Pear1provided by MGI
Official Full Name
platelet endothelial aggregation receptor 1provided by MGI
Primary source
MGI:MGI:1920432
See related
Ensembl:ENSMUSG00000028073 AllianceGenome:MGI:1920432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jedi-1; Megf12; 3110045G13Rik
Summary
Enables signaling receptor activity. Involved in phosphatidylinositol 3-kinase signaling; platelet aggregation; and protein kinase B signaling. Acts upstream of or within recognition of apoptotic cell. Located in phagocytic cup. Is active in plasma membrane. Is expressed in brain; dorsal root ganglion; embryo; and heart. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 34.7), mammary gland adult (RPKM 30.0) and 24 other tissues See more
Orthologs
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Genomic context

Location:
3 F1; 3 38.5 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87656404..87676262, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87749097..87769110, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 11 Neighboring gene predicted gene 6570 Neighboring gene leucine rich repeat containing 71 Neighboring gene neurotrophic tyrosine kinase, receptor, type 1 Neighboring gene insulin receptor-related receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General protein information

Preferred Names
platelet endothelial aggregation receptor 1
Names
Jedi
jagged and Delta protein
mPEAR1
multiple EGF-like domains protein 12
multiple epidermal growth factor-like domains protein 12
protein Jedi

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032413.1NP_001027585.1  platelet endothelial aggregation receptor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001027585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC122439, AK053551, BB848869
    Consensus CDS
    CCDS38474.1
    UniProtKB/Swiss-Prot
    Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5
    Related
    ENSMUSP00000133323.2, ENSMUST00000174759.8
    Conserved Domains (2) summary
    pfam07546
    Location:2593
    EMI; EMI domain
    cl21504
    Location:535580
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. NM_001032414.1NP_001027586.1  platelet endothelial aggregation receptor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001027586.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC122439, AF440279, AK014179, BB848869
    Consensus CDS
    CCDS38474.1
    UniProtKB/Swiss-Prot
    Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5
    Related
    ENSMUSP00000078090.6, ENSMUST00000079083.12
    Conserved Domains (2) summary
    pfam07546
    Location:2593
    EMI; EMI domain
    cl21504
    Location:535580
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  3. NM_001289600.1NP_001276529.1  platelet endothelial aggregation receptor 1 isoform b

    See identical proteins and their annotated locations for NP_001276529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice junction at the 5' end of an exon, which causes translation initiation at an alternate start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC161454, AK141082, BB848869
    UniProtKB/Swiss-Prot
    Q8VIK5
    Conserved Domains (1) summary
    cl21504
    Location:456501
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  4. NM_001289601.1NP_001276530.1  platelet endothelial aggregation receptor 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has several internal differences, which causes translation initiation at an alternate start codon, compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC161454, AK141082, AK161049, BB848869
    UniProtKB/Swiss-Prot
    Q8VIK5
    Conserved Domains (2) summary
    NF033759
    Location:171369
    exchanger_TraA; outer membrane exchange protein TraA
    cl21504
    Location:283328
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  5. NM_028460.2NP_082736.1  platelet endothelial aggregation receptor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_082736.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC122439, AF440279, BB848869
    Consensus CDS
    CCDS38474.1
    UniProtKB/Swiss-Prot
    Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5
    Related
    ENSMUSP00000133474.2, ENSMUST00000172621.8
    Conserved Domains (2) summary
    pfam07546
    Location:2593
    EMI; EMI domain
    cl21504
    Location:535580
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  6. NM_152799.2NP_690012.2  platelet endothelial aggregation receptor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_690012.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC122439, AF440279, BB848869, BY236825
    Consensus CDS
    CCDS38474.1
    UniProtKB/Swiss-Prot
    Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5
    Conserved Domains (2) summary
    pfam07546
    Location:2593
    EMI; EMI domain
    cl21504
    Location:535580
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87656404..87676262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163352.1XP_036019245.1  platelet endothelial aggregation receptor 1 isoform X1

    Conserved Domains (2) summary
    NF033759
    Location:171369
    exchanger_TraA; outer membrane exchange protein TraA
    cl21504
    Location:283328
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...