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Tm7sf2 transmembrane 7 superfamily member 2 [ Mus musculus (house mouse) ]

Gene ID: 73166, updated on 5-Jan-2023

Summary

Official Symbol
Tm7sf2provided by MGI
Official Full Name
transmembrane 7 superfamily member 2provided by MGI
Primary source
MGI:MGI:1920416
See related
Ensembl:ENSMUSG00000024799 AllianceGenome:MGI:1920416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ANG1; C14SR; Dhcr14; 3110041O18Rik
Summary
Enables delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in organelle membrane. Is expressed in several structures, including adrenal gland; alimentary system; eye; liver; and nervous system. Orthologous to human TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 170.8), liver E18 (RPKM 41.3) and 23 other tissues See more
Orthologs
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Genomic context

See Tm7sf2 in Genome Data Viewer
Location:
19; 19 A
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6112851..6117880, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6062821..6067850, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived) Neighboring gene zinc finger, HIT domain containing 2 Neighboring gene VPS51 GARP complex subunit Neighboring gene transmembrane protein 262 Neighboring gene zinc finger like protein 1 Neighboring gene cell division cycle associated 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delta14-sterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables delta14-sterol reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables delta14-sterol reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
delta(14)-sterol reductase TM7SF2
Names
3-beta-hydroxysterol Delta (14)-reductase
C-14 sterol reductase
delta-14-SR
sterol C14-reductase
NP_082730.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028454.2NP_082730.2  delta(14)-sterol reductase TM7SF2

    See identical proteins and their annotated locations for NP_082730.2

    Status: VALIDATED

    Source sequence(s)
    AF480070, AI846153, AK040016, BY551700
    Consensus CDS
    CCDS29490.2
    UniProtKB/Swiss-Prot
    B5LBK0, Q71KT5
    UniProtKB/TrEMBL
    Q3V3I6
    Related
    ENSMUSP00000025713.6, ENSMUST00000025713.12
    Conserved Domains (1) summary
    cl21511
    Location:8418
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6112851..6117880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)