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ACOD1 aconitate decarboxylase 1 [ Homo sapiens (human) ]

Gene ID: 730249, updated on 1-Jun-2020

Summary

Official Symbol
ACOD1provided by HGNC
Official Full Name
aconitate decarboxylase 1provided by HGNC
Primary source
HGNC:HGNC:33904
See related
Ensembl:ENSG00000102794 MIM:615275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAD; IRG1
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ACOD1 in Genome Data Viewer
Location:
13q22.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (76948511..76958638)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (77522694..77532777)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 12 Neighboring gene uncharacterized LOC105370269 Neighboring gene basic transcription factor 3 pseudogene 11 Neighboring gene ribosomal protein L7 pseudogene 44 Neighboring gene DEAH-box helicase 9 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
NHGRI GWA Catalog
Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aconitate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aconitate decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to interferon-beta ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interferon-gamma ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-1 ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to molecule of bacterial origin ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to progesterone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response IDA
Inferred from Direct Assay
more info
PubMed 
embryo implantation ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of toll-like receptor 2 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of toll-like receptor 4 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of type I interferon production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of antimicrobial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
tolerance induction to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cis-aconitate decarboxylase
Names
cis-aconitic acid decarboxylase
immune-responsive gene 1 protein homolog
immunoresponsive 1 homolog
NP_001245335.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258406.2NP_001245335.1  cis-aconitate decarboxylase

    See identical proteins and their annotated locations for NP_001245335.1

    Status: VALIDATED

    Source sequence(s)
    AC000403, AI652725, BX105915, DN831390
    Consensus CDS
    CCDS58299.1
    UniProtKB/Swiss-Prot
    A6NK06
    Related
    ENSP00000366682.1, ENST00000377462.6
    Conserved Domains (1) summary
    pfam03972
    Location:8449
    MmgE_PrpD; MmgE/PrpD family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    76948511..76958638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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