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SEC14L6 SEC14 like lipid binding 6 [ Homo sapiens (human) ]

Gene ID: 730005, updated on 14-Dec-2021

Summary

Official Symbol
SEC14L6provided by HGNC
Official Full Name
SEC14 like lipid binding 6provided by HGNC
Primary source
HGNC:HGNC:40047
See related
Ensembl:ENSG00000214491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in lung (RPKM 3.6), kidney (RPKM 2.7) and 10 other tissues See more
Orthologs
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Genomic context

See SEC14L6 in Genome Data Viewer
Location:
22q12.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (30522797..30546741, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30918775..30942669, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985579 Neighboring gene SEC14 like lipid binding 4 Neighboring gene signal regulatory protein alpha pseudogene 1 Neighboring gene galactose-3-O-sulfotransferase 1 Neighboring gene pescadillo ribosomal biogenesis factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative SEC14-like protein 6
Names
SEC14-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193336.4NP_001180265.2  putative SEC14-like protein 6 isoform 1

    See identical proteins and their annotated locations for NP_001180265.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC004832
    Consensus CDS
    CCDS54518.1
    UniProtKB/Swiss-Prot
    B5MCN3
    Related
    ENSP00000385695.1, ENST00000402034.7
    Conserved Domains (3) summary
    smart01100
    Location:1359
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:83244
    CRAL_TRIO; CRAL/TRIO domain
    pfam13897
    Location:284381
    GOLD_2; Golgi-dynamics membrane-trafficking
  2. NM_001353441.2NP_001340370.1  putative SEC14-like protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC004832
    Related
    ENSP00000509726.1, ENST00000687338.1
    Conserved Domains (1) summary
    pfam00650
    Location:29190
    CRAL_TRIO; CRAL/TRIO domain
  3. NM_001353443.2NP_001340372.1  putative SEC14-like protein 6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate 3' exon compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004832
    Related
    ENSP00000510258.1, ENST00000687231.1
    Conserved Domains (1) summary
    pfam00650
    Location:29190
    CRAL_TRIO; CRAL/TRIO domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    30522797..30546741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028933.1XP_016884422.1  putative SEC14-like protein 6 isoform X7

  2. XM_017028931.1XP_016884420.1  putative SEC14-like protein 6 isoform X1

  3. XM_011530360.2XP_011528662.1  putative SEC14-like protein 6 isoform X5

    Conserved Domains (2) summary
    pfam00650
    Location:100198
    CRAL_TRIO; CRAL/TRIO domain
    pfam13897
    Location:238335
    GOLD_2; Golgi-dynamics membrane-trafficking
  4. XM_011530358.2XP_011528660.1  putative SEC14-like protein 6 isoform X4

    Conserved Domains (2) summary
    pfam00650
    Location:100229
    CRAL_TRIO; CRAL/TRIO domain
    pfam13897
    Location:269366
    GOLD_2; Golgi-dynamics membrane-trafficking
  5. XM_011530357.2XP_011528659.1  putative SEC14-like protein 6 isoform X3

    Conserved Domains (2) summary
    pfam00650
    Location:100261
    CRAL_TRIO; CRAL/TRIO domain
    pfam13897
    Location:301398
    GOLD_2; Golgi-dynamics membrane-trafficking
  6. XM_024452266.1XP_024308034.1  putative SEC14-like protein 6 isoform X2

    Related
    ENSP00000510727.1, ENST00000691669.1
    Conserved Domains (1) summary
    pfam00650
    Location:272344
    CRAL_TRIO; CRAL/TRIO domain
  7. XM_024452267.1XP_024308035.1  putative SEC14-like protein 6 isoform X6

    Conserved Domains (1) summary
    pfam00650
    Location:100261
    CRAL_TRIO; CRAL/TRIO domain
  8. XM_024452268.1XP_024308036.1  putative SEC14-like protein 6 isoform X8

    Conserved Domains (1) summary
    pfam00650
    Location:29222
    CRAL_TRIO; CRAL/TRIO domain
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