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Ccser2 coiled-coil serine rich 2 [ Mus musculus (house mouse) ]

Gene ID: 72972, updated on 18-Sep-2024

Summary

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Official Symbol
Ccser2provided by MGI
Official Full Name
coiled-coil serine rich 2provided by MGI
Primary source
MGI:MGI:101859
See related
Ensembl:ENSMUSG00000058690 AllianceGenome:MGI:101859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcap14; Fam190b; 1700012P13Rik; 2900054P12Rik
Summary
Enables microtubule binding activity. Acts upstream of or within microtubule bundle formation. Located in microtubule cytoskeleton. Is expressed in cranial ganglion; dorsal root ganglion; rest of cerebellum marginal layer; sensory organ; and thymus primordium. Orthologous to human CCSER2 (coiled-coil serine rich protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 16.1), kidney adult (RPKM 14.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ccser2 in Genome Data Viewer
Location:
14 B; 14 21.29 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (36596893..36690762, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (36874936..36968841, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene STARR-seq mESC enhancer starr_36414 Neighboring gene predicted gene, 25204 Neighboring gene STARR-positive B cell enhancer ABC_E3109 Neighboring gene STARR-seq mESC enhancer starr_36416 Neighboring gene predicted gene, 53853 Neighboring gene STARR-seq mESC enhancer starr_36418 Neighboring gene STARR-positive B cell enhancer ABC_E8553 Neighboring gene STARR-seq mESC enhancer starr_36421 Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 Neighboring gene retinal G protein coupled receptor Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The murine Gcap14 gene encodes a novel microtubule binding and bundling protein. Hosono H, et al. FEBS Lett, 2012 May 21. PMID 22673506
  2. Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment. Mun DJ, et al. Proc Natl Acad Sci U S A, 2023 Feb 21. PMID 36795749, Free PMC Article
  3. Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Kambouris M, et al. Brain Res Mol Brain Res, 1994 Sep. PMID 7808216
  4. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.
    Title: Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule bundle formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine-rich coiled-coil domain-containing protein 2
Names
coiled-coil serine-rich protein 2
granule cell antiserum positive 14
granule cell antiserum positive protein 14
protein FAM190B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347502.1 → NP_001334431.1  serine-rich coiled-coil domain-containing protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and shorter 3' UTR. The encoded protein (isoform 2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK147383, BC111465, BM214039
    Consensus CDS
    CCDS84113.1
    UniProtKB/Swiss-Prot
    Q3UHI0

  2. NM_001347503.1 → NP_001334432.1  serine-rich coiled-coil domain-containing protein 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154655, AK147383, BM214039, CJ103616, CV556741
    Consensus CDS
    CCDS84112.1
    UniProtKB/TrEMBL
    S4R211, S4R2U3
    Related
    ENSMUSP00000138453.2, ENSMUST00000182042.2

  3. NM_027045.1 → NP_081321.1  serine-rich coiled-coil domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_081321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK147383, BB871809, BM214039, CV556741
    Consensus CDS
    CCDS26948.1
    UniProtKB/Swiss-Prot
    B2RT11, Q2NKY3, Q3TA20, Q3UHI0, Q6ZPX3, Q9DAD5
    Related
    ENSMUSP00000087478.4, ENSMUST00000090024.11

  4. NM_028407.4 → NP_082683.2  serine-rich coiled-coil domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_082683.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different 5' UTR segment, uses a downstream start codon, and lacks a segment in the 3' coding region, compared to variant 1. These changes result in a frameshift. The encoded protein (isoform 2) has a shorter N-terminus and a distinct C-terminus when compared to isoform 1.
    Source sequence(s)
    AC154655, AC158525
    Consensus CDS
    CCDS26947.1
    UniProtKB/TrEMBL
    A0A0R4J2A7
    Related
    ENSMUSP00000138718.2, ENSMUST00000183038.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    36596893..36690762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248048.2 → XP_030103908.1  serine-rich coiled-coil domain-containing protein 2 isoform X2

    Related
    ENSMUSP00000068550.7, ENSMUST00000067700.13

  2. XM_006519606.5 → XP_006519669.1  serine-rich coiled-coil domain-containing protein 2 isoform X5

  3. XM_006519605.4 → XP_006519668.1  serine-rich coiled-coil domain-containing protein 2 isoform X4

  4. XM_011245208.4 → XP_011243510.1  serine-rich coiled-coil domain-containing protein 2 isoform X3

  5. XM_036158858.1 → XP_036014751.1  serine-rich coiled-coil domain-containing protein 2 isoform X1

  6. XM_036158860.1 → XP_036014753.1  serine-rich coiled-coil domain-containing protein 2 isoform X7

  7. XM_006519607.3 → XP_006519670.1  serine-rich coiled-coil domain-containing protein 2 isoform X9

  8. XM_036158861.1 → XP_036014754.1  serine-rich coiled-coil domain-containing protein 2 isoform X8

  9. XM_036158863.1 → XP_036014756.1  serine-rich coiled-coil domain-containing protein 2 isoform X10

    UniProtKB/TrEMBL
    S4R211, S4R2U3

  10. XM_036158862.1 → XP_036014755.1  serine-rich coiled-coil domain-containing protein 2 isoform X8

  11. XM_036158859.1 → XP_036014752.1  serine-rich coiled-coil domain-containing protein 2 isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHI0.1 GenPept UniProtKB/Swiss-Prot:Q3UHI0

Gene LinkOut

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