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SPDYE6 speedy/RINGO cell cycle regulator family member E6 [ Homo sapiens (human) ]

Gene ID: 729597, updated on 5-Jan-2022

Summary

Official Symbol
SPDYE6provided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member E6provided by HGNC
Primary source
HGNC:HGNC:35465
See related
Ensembl:ENSG00000260097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a cell cycle regulatory protein which plays an important role in cell cycle progression by binding and activating cyclin-dependent kinases. The encoded protein belongs to a family of cyclin-dependent kinase regulators that contain a speedy box domain which is required for cyclin-dependent kinase activation. [provided by RefSeq, Jul 2017]
Expression
Broad expression in testis (RPKM 6.2), spleen (RPKM 2.1) and 22 other tissues See more
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Genomic context

See SPDYE6 in Genome Data Viewer
Location:
7q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (102345746..102356444, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (101986186..101996889, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986717 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 12 Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene uncharacterized LOC100289561 Neighboring gene PRKR interacting protein 1 Neighboring gene microRNA 548o

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General protein information

Preferred Names
speedy protein E6
Names
Putative speedy protein E6
speedy homolog E6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146210.4NP_001139682.2  speedy protein E6

    See identical proteins and their annotated locations for NP_001139682.2

    Status: REVIEWED

    Source sequence(s)
    AC091390, HY053642
    Consensus CDS
    CCDS78265.1
    UniProtKB/TrEMBL
    A0A096LNU6
    Related
    ENSP00000485230.1, ENST00000563237.3
    Conserved Domains (1) summary
    pfam11357
    Location:194398
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    102345746..102356444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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