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SPDYE6 speedy/RINGO cell cycle regulator family member E6 [ Homo sapiens (human) ]

Gene ID: 729597, updated on 2-Nov-2024

Summary

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Official Symbol
SPDYE6provided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member E6provided by HGNC
Primary source
HGNC:HGNC:35465
See related
Ensembl:ENSG00000260097 AllianceGenome:HGNC:35465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a cell cycle regulatory protein which plays an important role in cell cycle progression by binding and activating cyclin-dependent kinases. The encoded protein belongs to a family of cyclin-dependent kinase regulators that contain a speedy box domain which is required for cyclin-dependent kinase activation. [provided by RefSeq, Jul 2017]
Expression
Broad expression in testis (RPKM 6.2), spleen (RPKM 2.1) and 22 other tissues See more
Orthologs
all
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Genomic context

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See SPDYE6 in Genome Data Viewer
Location:
7q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102345746..102356444, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103663168..103673862, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (101986186..101996889, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986717 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26426 Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene uncharacterized LOC100289561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18503 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102036787-102037328 Neighboring gene PRKR interacting protein 1 Neighboring gene uncharacterized LOC105375433 Neighboring gene microRNA 548o

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Gopinathan L, et al. Results Probl Cell Differ, 2011. PMID 21630153
  2. CDK activation by non-cyclin proteins. Nebreda AR. Curr Opin Cell Biol, 2006 Apr. PMID 16488127
  3. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. Chauhan S, et al. Cell Mol Life Sci, 2012 Nov. PMID 22763696, Free PMC Article
  4. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cheng A, et al. Cell Cycle, 2005 Jan. PMID 15611625
  5. Characterization of a new family of cyclin-dependent kinase activators. Dinarina A, et al. Biochem J, 2005 Mar 1. PMID 15574121, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
speedy protein E6
Names
Putative speedy protein E6
speedy homolog E6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146210.4 → NP_001139682.2  speedy protein E6

    See identical proteins and their annotated locations for NP_001139682.2

    Status: REVIEWED

    Source sequence(s)
    AC091390, HY053642
    Consensus CDS
    CCDS78265.1
    UniProtKB/Swiss-Prot
    A0A096LNU6, P0CI01
    Related
    ENSP00000485230.1, ENST00000563237.3
    Conserved Domains (1) summary
    pfam11357
    Location:194 → 398
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    102345746..102356444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420794.1 → XP_047276750.1  speedy protein E6 isoform X2

    UniProtKB/Swiss-Prot
    A0A096LNU6, P0CI01

  2. XM_047420793.1 → XP_047276749.1  speedy protein E6 isoform X1

  3. XM_047420795.1 → XP_047276751.1  speedy protein E6 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    103663168..103673862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358927.1 → XP_054214902.1  speedy protein E6 isoform X4

  2. XM_054358926.1 → XP_054214901.1  speedy protein E6 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CI01.2 GenPept UniProtKB/Swiss-Prot:P0CI01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials