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RGPD6 RANBP2 like and GRIP domain containing 6 [ Homo sapiens (human) ]

Gene ID: 729540, updated on 27-Nov-2024

Summary

Official Symbol
RGPD6provided by HGNC
Official Full Name
RANBP2 like and GRIP domain containing 6provided by HGNC
Primary source
HGNC:HGNC:32419
See related
Ensembl:ENSG00000183054 MIM:612709; AllianceGenome:HGNC:32419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP6; RGPD7; RanBP2L1; RanBP2L2
Summary
Predicted to be involved in intracellular transport. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 24.0), brain (RPKM 8.3) and 25 other tissues See more
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Genomic context

See RGPD6 in Genome Data Viewer
Location:
2q13
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110513802..110611056, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (110936277..111033955, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111271379..111368633, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LIM zinc finger domain containing 4 Neighboring gene uncharacterized LOC105373552 Neighboring gene uncharacterized LOC102724875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111339275-111339775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111367745-111368317 Neighboring gene uncharacterized LOC105373553 Neighboring gene ribosomal protein L22 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC190070

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
RANBP2-like and GRIP domain-containing protein 5/6
Names
RANBP2-like and GRIP domain-containing protein 7
ran-binding protein 2-like 1/2
ranBP2-like 1/2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037866.2NP_001032955.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 2

    See identical proteins and their annotated locations for NP_001032955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC108938, AC226101
    Consensus CDS
    CCDS42729.1
    Related
    ENSP00000330023.5, ENST00000330331.9
    Conserved Domains (3) summary
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6092
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  2. NM_001123363.4NP_001116835.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 1

    See identical proteins and their annotated locations for NP_001116835.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC108938, AC226101
    Consensus CDS
    CCDS46388.1
    UniProtKB/Swiss-Prot
    Q53QN2, Q53T03, Q59GM7, Q99666, Q9H0B2
    UniProtKB/TrEMBL
    A0A8Q3SIN4, V9HWE4
    Related
    ENSP00000330842.3, ENST00000329516.8
    Conserved Domains (8) summary
    COG5171
    Location:9751167
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10511167
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13481464
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6092
    TPR_1; Tetratricopeptide repeat
    pfam01465
    Location:17071749
    GRIP; GRIP domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
    pfam16704
    Location:16411705
    Rab_bind; Rab binding domain
  3. NM_001384362.1NP_001371291.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    UniProtKB/TrEMBL
    J3KQ37
    Conserved Domains (4) summary
    cd13177
    Location:766882
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:10631179
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    pfam16704
    Location:13561420
    Rab_bind; Rab binding domain
    pfam01465
    Location:14221464
    GRIP; GRIP domain
  4. NM_001384363.1NP_001371292.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    Consensus CDS
    CCDS92839.1
    UniProtKB/TrEMBL
    A0A8Q3SII4, A0A8Q3SIN4
    Related
    ENSP00000512635.1, ENST00000696448.1
    Conserved Domains (7) summary
    COG0457
    Location:13109
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13177
    Location:10341150
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13311447
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:4272
    TPR; TPR repeat [structural motif]
    pfam16704
    Location:16241688
    Rab_bind; Rab binding domain
    pfam00515
    Location:4375
    TPR_1; Tetratricopeptide repeat
    pfam01465
    Location:16901732
    GRIP; GRIP domain
  5. NM_001384364.1NP_001371293.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    UniProtKB/TrEMBL
    A0A8Q3SIN4
    Conserved Domains (7) summary
    COG0457
    Location:4100
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13177
    Location:10251141
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13221438
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:3363
    TPR; TPR repeat [structural motif]
    pfam16704
    Location:16151679
    Rab_bind; Rab binding domain
    pfam00515
    Location:3466
    TPR_1; Tetratricopeptide repeat
    pfam01465
    Location:16811723
    GRIP; GRIP domain
  6. NM_001386141.1NP_001373070.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    UniProtKB/TrEMBL
    J3KQ37
    Conserved Domains (4) summary
    cd13177
    Location:766882
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:10631179
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    pfam16704
    Location:13561420
    Rab_bind; Rab binding domain
    pfam01465
    Location:14221464
    GRIP; GRIP domain
  7. NM_001386145.1NP_001373074.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    UniProtKB/TrEMBL
    A0A8Q3SIN4
    Conserved Domains (7) summary
    COG0457
    Location:29125
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd13177
    Location:10501166
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13471463
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5888
    TPR; TPR repeat [structural motif]
    pfam16704
    Location:16401704
    Rab_bind; Rab binding domain
    pfam00515
    Location:5991
    TPR_1; Tetratricopeptide repeat
    pfam01465
    Location:17061748
    GRIP; GRIP domain
  8. NM_001386155.1NP_001373084.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    UniProtKB/TrEMBL
    J3KQ37
    Conserved Domains (4) summary
    cd13177
    Location:766882
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:10631179
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    pfam16704
    Location:13561420
    Rab_bind; Rab binding domain
    pfam01465
    Location:14221464
    GRIP; GRIP domain
  9. NM_001386159.1NP_001373088.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    UniProtKB/TrEMBL
    J3KQ37
    Conserved Domains (4) summary
    cd13177
    Location:766882
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:10631179
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    pfam16704
    Location:13561420
    Rab_bind; Rab binding domain
    pfam01465
    Location:14221464
    GRIP; GRIP domain
  10. NM_001386163.1NP_001373092.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    UniProtKB/TrEMBL
    B4DTT2
    Conserved Domains (4) summary
    cd13177
    Location:396512
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:693809
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    pfam16704
    Location:9861050
    Rab_bind; Rab binding domain
    pfam01465
    Location:10521094
    GRIP; GRIP domain
  11. NM_001387273.1NP_001374202.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
    UniProtKB/TrEMBL
    J3KQ37
    Conserved Domains (4) summary
    cd13177
    Location:766882
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:10631179
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    pfam16704
    Location:13561420
    Rab_bind; Rab binding domain
    pfam01465
    Location:14221464
    GRIP; GRIP domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    110513802..110611056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445731.1XP_047301687.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X2

  2. XM_047445732.1XP_047301688.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X3

  3. XM_017004839.2XP_016860328.2  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1

  4. XM_047445733.1XP_047301689.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X8

  5. XM_017004841.2XP_016860330.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X4

    UniProtKB/TrEMBL
    A0A8Q3SIN4
  6. XM_011511770.3XP_011510072.2  RANBP2-like and GRIP domain-containing protein 5/6 isoform X7

    UniProtKB/TrEMBL
    A0A8Q3SII5
    Related
    ENSP00000512636.1, ENST00000696449.1
  7. XM_011511769.3XP_011510071.2  RANBP2-like and GRIP domain-containing protein 5/6 isoform X5

  8. XM_017004843.2XP_016860332.2  RANBP2-like and GRIP domain-containing protein 5/6 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    110936277..111033955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343727.1XP_054199702.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1

  2. XM_054343732.1XP_054199707.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X8

  3. XM_054343728.1XP_054199703.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X4

  4. XM_054343731.1XP_054199706.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X7

    UniProtKB/TrEMBL
    A0A8Q3SII5
  5. XM_054343729.1XP_054199704.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X5

  6. XM_054343730.1XP_054199705.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_169873.1: Suppressed sequence

    Description
    NR_169873.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.