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RGPD6 RANBP2 like and GRIP domain containing 6 [ Homo sapiens (human) ]

Gene ID: 729540, updated on 24-Nov-2020

Summary

Official Symbol
RGPD6provided by HGNC
Official Full Name
RANBP2 like and GRIP domain containing 6provided by HGNC
Primary source
HGNC:HGNC:32419
See related
Ensembl:ENSG00000183054 MIM:612709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP6; RGPD7; RanBP2L1; RanBP2L2
Expression
Broad expression in testis (RPKM 24.0), brain (RPKM 8.3) and 25 other tissues See more

Genomic context

See RGPD6 in Genome Data Viewer
Location:
2q13
Exon count:
30
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (110513802..110611056, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111271379..111336309, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LIM zinc finger domain containing 4 Neighboring gene uncharacterized LOC105373552 Neighboring gene uncharacterized LOC102724875 Neighboring gene uncharacterized LOC105373553 Neighboring gene ribosomal protein L22 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC190070

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RANBP2-like and GRIP domain-containing protein 5/6
Names
RANBP2-like and GRIP domain-containing protein 7
ran-binding protein 2-like 1/2
ranBP2-like 1/2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037866.2NP_001032955.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 2

    See identical proteins and their annotated locations for NP_001032955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC108938, AC226101
    Consensus CDS
    CCDS42729.1
    UniProtKB/Swiss-Prot
    Q99666
    Related
    ENSP00000330023.5, ENST00000330331.9
    Conserved Domains (3) summary
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6092
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:59126
    TPR_11; TPR repeat
  2. NM_001123363.4NP_001116835.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 1

    See identical proteins and their annotated locations for NP_001116835.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC108938, AC226101
    Consensus CDS
    CCDS46388.1
    UniProtKB/Swiss-Prot
    Q99666
    UniProtKB/TrEMBL
    V9HWE4
    Related
    ENSP00000330842.3, ENST00000329516.7
    Conserved Domains (8) summary
    COG5171
    Location:9751167
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10511167
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13481464
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5989
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:6092
    TPR_1; Tetratricopeptide repeat
    pfam01465
    Location:17071749
    GRIP; GRIP domain
    pfam13414
    Location:59126
    TPR_11; TPR repeat
    pfam16704
    Location:16411705
    Rab_bind; Rab binding domain
  3. NM_001384362.1NP_001371291.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
  4. NM_001384363.1NP_001371292.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
  5. NM_001384364.1NP_001371293.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
  6. NM_001386141.1NP_001373070.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
  7. NM_001386145.1NP_001373074.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
  8. NM_001386155.1NP_001373084.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
  9. NM_001386159.1NP_001373088.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
  10. NM_001386163.1NP_001373092.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101
  11. NM_001387273.1NP_001374202.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108938, AC226101

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    110513802..110611056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004839.1XP_016860328.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1

  2. XM_017004840.2XP_016860329.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X3

  3. XM_017004841.1XP_016860330.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X4

  4. XM_024453119.1XP_024308887.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X9

    Conserved Domains (2) summary
    cd13177
    Location:396512
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:693809
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
  5. XM_011511770.2XP_011510072.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X8

    Conserved Domains (6) summary
    COG5171
    Location:10041196
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10801196
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13771493
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:88118
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:89121
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:88155
    TPR_11; TPR repeat
  6. XM_011511769.2XP_011510071.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X6

    Conserved Domains (6) summary
    COG5171
    Location:10041196
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10801196
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13771493
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:88118
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:89121
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:88155
    TPR_11; TPR repeat
  7. XM_017004843.1XP_016860332.1  RANBP2-like and GRIP domain-containing protein 5/6 isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_169873.1: Suppressed sequence

    Description
    NR_169873.1: This RefSeq was removed because it is now thought that this transcript does encode a protein.
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