Format

Send to:

Choose Destination

TXK TXK tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 7294, updated on 7-Dec-2018

Summary

Official Symbol
TXKprovided by HGNC
Official Full Name
TXK tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:12434
See related
Ensembl:ENSG00000074966 MIM:600058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RLK; TKL; BTKL; PTK4; PSCTK5
Expression
Broad expression in lymph node (RPKM 5.7), spleen (RPKM 3.3) and 15 other tissues See more
Orthologs

Genomic context

See TXK in Genome Data Viewer
Location:
4p12
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (48063504..48135322, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48068410..48136273, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927157 Neighboring gene cyclic nucleotide gated channel alpha 1 Neighboring gene NIPA like domain containing 1 Neighboring gene RNA, U6 small nuclear 838, pseudogene Neighboring gene tec protein tyrosine kinase Neighboring gene uncharacterized LOC105374445

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • FCERI mediated Ca+2 mobilization, organism-specific biosystem (from REACTOME)
    FCERI mediated Ca+2 mobilization, organism-specific biosystemIncrease of intracellular calcium in mast cells is most crucial for mast cell degranulation. Elevation of intracellular calcium is achieved by activation of PLC-gamma. Mast cells express both PLC-gam...
  • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
    Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein kinase TXK
Names
PTK4 protein tyrosine kinase 4
protein-tyrosine kinase 4
resting lymphocyte kinase
NP_003319.2
XP_011512049.1
XP_011512050.1
XP_016864070.1
XP_016864071.1
XP_024309968.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003328.3NP_003319.2  tyrosine-protein kinase TXK

    See identical proteins and their annotated locations for NP_003319.2

    Status: VALIDATED

    Source sequence(s)
    AC096749, DB103575, L27071
    Consensus CDS
    CCDS3480.1
    UniProtKB/Swiss-Prot
    P42681
    Related
    ENSP00000264316.4, ENST00000264316.8
    Conserved Domains (4) summary
    cd05059
    Location:266521
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:143248
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:85139
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
    pfam07714
    Location:271518
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    48063504..48135322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008581.2XP_016864070.1  tyrosine-protein kinase TXK isoform X3

  2. XM_011513747.3XP_011512049.1  tyrosine-protein kinase TXK isoform X2

    Conserved Domains (4) summary
    cd05059
    Location:247502
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:131229
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    pfam07714
    Location:252499
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:88130
    SH3; Src Homology 3 domain superfamily
  3. XM_024454200.1XP_024309968.1  tyrosine-protein kinase TXK isoform X1

    Conserved Domains (3) summary
    cd05059
    Location:269524
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:146251
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:88142
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
  4. XM_017008582.2XP_016864071.1  tyrosine-protein kinase TXK isoform X4

  5. XM_011513748.3XP_011512050.1  tyrosine-protein kinase TXK isoform X5

    Conserved Domains (2) summary
    pfam07714
    Location:33280
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:28287
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_925166.3 RNA Sequence

Support Center