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TXK TXK tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 7294, updated on 11-Apr-2024

Summary

Official Symbol
TXKprovided by HGNC
Official Full Name
TXK tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:12434
See related
Ensembl:ENSG00000074966 MIM:600058; AllianceGenome:HGNC:12434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RLK; TKL; BTKL; PTK4; PSCTK5
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 5.7), spleen (RPKM 3.3) and 15 other tissues See more
Orthologs
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Genomic context

See TXK in Genome Data Viewer
Location:
4p12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (48066393..48134250, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (48033459..48101082, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48068410..48136267, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927157 Neighboring gene cyclic nucleotide gated channel subunit alpha 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:48013506-48014020 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:48014021-48014534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:48018379-48018880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21535 Neighboring gene NIPA like domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21536 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:48095793-48096992 Neighboring gene uncharacterized LOC124900886 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:48114113-48115312 Neighboring gene RNA, U6 small nuclear 838, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:48129156-48130018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21537 Neighboring gene Sharpr-MPRA regulatory region 15119 Neighboring gene NANOG hESC enhancer GRCh37_chr4:48177274-48177775 Neighboring gene tec protein tyrosine kinase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48187797-48188522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15405 Neighboring gene uncharacterized LOC105374445 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:48293363-48294358

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC22473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in activation of phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type II interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tyrosine-protein kinase TXK
Names
PTK4 protein tyrosine kinase 4
protein-tyrosine kinase 4
resting lymphocyte kinase
NP_003319.2
XP_011512049.1
XP_011512050.1
XP_016864070.1
XP_024309968.1
XP_047272078.1
XP_047272079.1
XP_047272081.1
XP_054206748.1
XP_054206749.1
XP_054206750.1
XP_054206751.1
XP_054206752.1
XP_054206753.1
XP_054206754.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003328.3NP_003319.2  tyrosine-protein kinase TXK

    See identical proteins and their annotated locations for NP_003319.2

    Status: VALIDATED

    Source sequence(s)
    AC096749, DB103575, L27071
    Consensus CDS
    CCDS3480.1
    UniProtKB/Swiss-Prot
    P42681, Q14220
    UniProtKB/TrEMBL
    E7EQN8
    Related
    ENSP00000264316.4, ENST00000264316.9
    Conserved Domains (3) summary
    cd05059
    Location:266521
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:143248
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:85139
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    48066393..48134250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008581.3XP_016864070.1  tyrosine-protein kinase TXK isoform X3

    UniProtKB/TrEMBL
    E7EQN8
  2. XM_011513747.4XP_011512049.1  tyrosine-protein kinase TXK isoform X2

    UniProtKB/TrEMBL
    E7EQN8
    Conserved Domains (4) summary
    cd05059
    Location:247502
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:131229
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    pfam07714
    Location:252499
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:88130
    SH3; Src Homology 3 domain superfamily
  3. XM_024454200.2XP_024309968.1  tyrosine-protein kinase TXK isoform X1

    UniProtKB/TrEMBL
    E7EQN8
    Conserved Domains (3) summary
    cd05059
    Location:269524
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:146251
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:88142
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
  4. XM_047416123.1XP_047272079.1  tyrosine-protein kinase TXK isoform X5

  5. XM_011513748.4XP_011512050.1  tyrosine-protein kinase TXK isoform X6

    Conserved Domains (2) summary
    pfam07714
    Location:33280
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:28287
    PKc_like; Protein Kinases, catalytic domain
  6. XM_047416122.1XP_047272078.1  tyrosine-protein kinase TXK isoform X4

  7. XM_047416125.1XP_047272081.1  tyrosine-protein kinase TXK isoform X7

RNA

  1. XR_007057955.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    48033459..48101082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350775.1XP_054206750.1  tyrosine-protein kinase TXK isoform X3

  2. XM_054350774.1XP_054206749.1  tyrosine-protein kinase TXK isoform X2

  3. XM_054350773.1XP_054206748.1  tyrosine-protein kinase TXK isoform X1

  4. XM_054350777.1XP_054206752.1  tyrosine-protein kinase TXK isoform X5

  5. XM_054350778.1XP_054206753.1  tyrosine-protein kinase TXK isoform X6

  6. XM_054350776.1XP_054206751.1  tyrosine-protein kinase TXK isoform X4

  7. XM_054350779.1XP_054206754.1  tyrosine-protein kinase TXK isoform X7

RNA

  1. XR_008487028.1 RNA Sequence