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SLC15A5 solute carrier family 15 member 5 [ Homo sapiens (human) ]

Gene ID: 729025, updated on 23-Nov-2023

Summary

Official Symbol
SLC15A5provided by HGNC
Official Full Name
solute carrier family 15 member 5provided by HGNC
Primary source
HGNC:HGNC:33455
See related
Ensembl:ENSG00000188991 MIM:620324; AllianceGenome:HGNC:33455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable symporter activity. Predicted to be involved in peptide transport; protein transport; and transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See SLC15A5 in Genome Data Viewer
Location:
12p12.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (16188485..16277685, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (16065864..16155028, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (16341419..16430619, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:16063956-16064700 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:16064701-16065444 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:16069411-16069624 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:16089367-16090566 Neighboring gene MPRA-validated peak1581 silencer Neighboring gene serine/threonine kinase receptor associated protein Neighboring gene deoxyribose-phosphate aldolase Neighboring gene VISTA enhancer hs798 Neighboring gene egl-9 family hypoxia-inducible factor 3 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3277 Neighboring gene uncharacterized LOC101928362 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:16499669-16500598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:16501529-16502458 Neighboring gene Sharpr-MPRA regulatory region 9686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:16535292-16535885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:16535886-16536478 Neighboring gene microsomal glutathione S-transferase 1 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:16602892-16603466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:16603467-16604039 Neighboring gene VISTA enhancer hs607 Neighboring gene GOT2 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
solute carrier family 15 member 5
Names
Peptide/histidine transporter ENSP00000340402

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170798.1NP_001164269.1  solute carrier family 15 member 5

    See identical proteins and their annotated locations for NP_001164269.1

    Status: VALIDATED

    Source sequence(s)
    AC073574
    UniProtKB/Swiss-Prot
    A6NIM6
    Related
    ENSP00000340402.3, ENST00000344941.3
    Conserved Domains (1) summary
    cl21472
    Location:139493
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    16188485..16277685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    16065864..16155028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)