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CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 [ Homo sapiens (human) ]

Gene ID: 728763, updated on 5-Jun-2022

Summary

Official Symbol
CROCC2provided by HGNC
Official Full Name
ciliary rootlet coiled-coil, rootletin family member 2provided by HGNC
Primary source
HGNC:HGNC:51677
See related
Ensembl:ENSG00000226321 AllianceGenome:HGNC:51677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in spleen (RPKM 1.3), lung (RPKM 0.7) and 7 other tissues See more
Orthologs
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Genomic context

See CROCC2 in Genome Data Viewer
Location:
2q37.3
Exon count:
32
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240906336..240993311)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241405592..241492295)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241845753..241932728)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene alanine--glyoxylate and serine--pyruvate aminotransferase Neighboring gene mab-21 like 4 Neighboring gene uncharacterized LOC112268440 Neighboring gene up-regulated in colorectal cancer liver metastasis Neighboring gene uncharacterized LOC107985787 Neighboring gene sushi, nidogen and EGF like domains 1 Neighboring gene SNED1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
ciliary rootlet coiled-coil protein 2
Names
putative ciliary rootlet coiled-coil protein 2
putative ciliary rootlet coiled-coil protein-like 3 protein
rootletin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351305.2NP_001338234.1  ciliary rootlet coiled-coil protein 2

    Status: VALIDATED

    Source sequence(s)
    AC104809, BU682871, BX091140, DT932542, DV080150, DV080240, DV080412, DV080499, DV080638, DY655377, DY655577, DY655578, EG327310, EG327700
    Related
    ENSP00000508848.1, ENST00000690015.1
    Conserved Domains (4) summary
    PTZ00121
    Location:10511639
    PTZ00121; MAEBL; Provisional
    COG4942
    Location:401606
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:5381293
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15035
    Location:120265
    Rootletin; Ciliary rootlet component, centrosome cohesion

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    240906336..240993311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453115.2XP_024308883.1  ciliary rootlet coiled-coil protein 2 isoform X1

    Conserved Domains (4) summary
    pfam15035
    Location:120265
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl25732
    Location:5381293
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:10511639
    Neuromodulin_N; Gap junction protein N-terminal region
    cl27539
    Location:401606
    Peptidase_M23; Peptidase family M23

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    241405592..241492295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)