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SPANXB1 SPANX family member B1 [ Homo sapiens (human) ]

Gene ID: 728695, updated on 11-Jun-2021

Summary

Official Symbol
SPANXB1provided by HGNC
Official Full Name
SPANX family member B1provided by HGNC
Primary source
HGNC:HGNC:14329
See related
Ensembl:ENSG00000227234 MIM:300669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B1; CT11.2; SPANXB; SPANX-B; SPANXB2; SPANXF1; SPANXF2
Summary
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014]
Expression
Restricted expression toward testis (RPKM 16.7) See more
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Genomic context

See SPANXB1 in Genome Data Viewer
Location:
Xq27.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (141002594..141003706)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (140084759..140085871)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cerebellar degeneration related protein 1 Neighboring gene microRNA 320d-2 Neighboring gene RNA, U6 small nuclear 3, pseudogene Neighboring gene RPL36A pseudogene 52

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC169156, MGC169159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in spermatid development NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
sperm protein associated with the nucleus on the X chromosome B1
Names
SPANX family member B/F
SPANX family member F1
SPANX family, member B2
SPANX family, member F2
cancer/testis antigen 11.2
cancer/testis antigen family 11, member 2
nuclear-associated protein SPAN-Xb
nuclear-associated protein SPAN-Xf
sperm protein associated with the nucleus on the X chromosome B/F
sperm protein associated with the nucleus, X chromosome, family member B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032461.4NP_115850.2  sperm protein associated with the nucleus on the X chromosome B1

    See identical proteins and their annotated locations for NP_115850.2

    Status: REVIEWED

    Source sequence(s)
    AJ457796
    Consensus CDS
    CCDS44006.1
    UniProtKB/Swiss-Prot
    Q9NS25
    Related
    ENSP00000405202.1, ENST00000449283.2
    Conserved Domains (1) summary
    pfam07458
    Location:288
    SPAN-X; Sperm protein associated with nucleus, mapped to X chromosome

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    141002594..141003706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145664.1: Suppressed sequence

    Description
    NM_145664.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for the SPANXB-type gene that is represented in the GRCh38 primary reference genome assembly.
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