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EIF3CL eukaryotic translation initiation factor 3 subunit C like [ Homo sapiens (human) ]

Gene ID: 728689, updated on 25-Jan-2022

Summary

Official Symbol
EIF3CLprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit C likeprovided by HGNC
Primary source
HGNC:HGNC:26347
See related
Ensembl:ENSG00000205609 AllianceGenome:HGNC:26347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in ovary (RPKM 103.1), thyroid (RPKM 97.8) and 25 other tissues See more
Orthologs
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Genomic context

See EIF3CL in Genome Data Viewer
Location:
16p12.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (28379581..28403885, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28390902..28415206, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SH3 domain binding kinase 1 Neighboring gene uncharacterized LOC105369182 Neighboring gene nuclear pore complex interacting protein family member B6 Neighboring gene microRNA 6862-1 Neighboring gene uncharacterized LOC112268171 Neighboring gene cell division cycle 37 pseudogene 2 Neighboring gene nuclear pore complex interacting protein family member B7 Neighboring gene CLN3 lysosomal/endosomal transmembrane protein, battenin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit C-like protein
Names
eIF3 p110
eukaryotic translation initiation factor 3 subunit 8
eukaryotic translation initiation factor 3, subunit 8, 110kDa-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099661.2NP_001093131.1  eukaryotic translation initiation factor 3 subunit C-like protein

    See identical proteins and their annotated locations for NP_001093131.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC138894, CA420261, DA645577, DC410988
    Consensus CDS
    CCDS42136.1
    UniProtKB/Swiss-Prot
    B5ME19
    Related
    ENSP00000381917.3, ENST00000398944.7
    Conserved Domains (2) summary
    smart00753
    Location:779867
    PAM; PCI/PINT associated module
    pfam05470
    Location:29706
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  2. NM_001317856.1NP_001304785.1  eukaryotic translation initiation factor 3 subunit C-like protein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC138894, BQ686089, CA420261, DC410988
    Consensus CDS
    CCDS42136.1
    UniProtKB/Swiss-Prot
    B5ME19
    Conserved Domains (2) summary
    smart00753
    Location:779867
    PAM; PCI/PINT associated module
    pfam05470
    Location:29706
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  3. NM_001317857.2NP_001304786.1  eukaryotic translation initiation factor 3 subunit C-like protein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. All three variants encode the same protein.
    Source sequence(s)
    AC138894, DC410988
    Consensus CDS
    CCDS42136.1
    UniProtKB/Swiss-Prot
    B5ME19
    Related
    ENSP00000370258.5, ENST00000380876.5
    Conserved Domains (2) summary
    smart00753
    Location:779867
    PAM; PCI/PINT associated module
    pfam05470
    Location:29706
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    28379581..28403885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023621.1XP_016879110.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X2

    UniProtKB/TrEMBL
    A0A024QYX7
    Conserved Domains (2) summary
    smart00088
    Location:462550
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam05470
    Location:2389
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  2. XM_017023620.2XP_016879109.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

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