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GGT2 gamma-glutamyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 728441, updated on 25-Nov-2021

Summary

Official Symbol
GGT2provided by HGNC
Official Full Name
gamma-glutamyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:4251
See related
Ensembl:ENSG00000133475 MIM:137181
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GGT; GGT 2
Summary
GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Expression
Biased expression in testis (RPKM 7.1), kidney (RPKM 4.7) and 11 other tissues See more
Orthologs
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Genomic context

See GGT2 in Genome Data Viewer
Location:
22q11.21
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (21207976..21259684, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21562262..21632151, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 230 member B Neighboring gene family with sequence similarity 247 member A Neighboring gene E2F transcription factor 6 pseudogene 3 Neighboring gene POM121 transmembrane nucleoporin like 8, pseudogene Neighboring gene BCR pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • gamma-glutamyltranspeptidase 2
  • glutathione hydrolase 2
  • inactive gamma-glutamyltranspeptidase 2
  • inactive glutathione hydrolase 2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables glutathione hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leukotriene D4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptide modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT involved_in zymogen activation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_172944.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000550, AP000551

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    21207976..21259684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001351304.1: Suppressed sequence

    Description
    NM_001351304.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
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