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KRTAP4-8 keratin associated protein 4-8 [ Homo sapiens (human) ]

Gene ID: 728224, updated on 5-Aug-2022

Summary

Official Symbol
KRTAP4-8provided by HGNC
Official Full Name
keratin associated protein 4-8provided by HGNC
Primary source
HGNC:HGNC:17230
See related
Ensembl:ENSG00000204880 AllianceGenome:HGNC:17230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP4.8; KRTAP4.8
Summary
Involved in aging and hair cycle. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See KRTAP4-8 in Genome Data Viewer
Location:
17q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41096981..41098142, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41961756..41962929, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39253233..39254394, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin associated protein 2-5, pseudogene Neighboring gene keratin associated protein 4-7 Neighboring gene keratin associated protein 4-16 Neighboring gene keratin associated protein 4-9

Genomic regions, transcripts, and products

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in aging IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hair cycle IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin-associated protein 4-8
Names
keratin associated protein 4.8
ultrahigh sulfur keratin-associated protein 4.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322457.1NP_001309386.1  keratin-associated protein 4-8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate allele located on the reference alternate locus, ALT_REF_LOCI_1.
    Source sequence(s)
    AC037482
    UniProtKB/TrEMBL
    A0A0G2JLE6
    Conserved Domains (2) summary
    pfam01500
    Location:5114
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:69113
    Keratin_B2_2; Keratin, high sulfur B2 protein
  2. NM_031960.3NP_114166.1  keratin-associated protein 4-8 isoform 1

    See identical proteins and their annotated locations for NP_114166.1

    Status: VALIDATED

    Source sequence(s)
    AC100808
    Consensus CDS
    CCDS45674.1
    UniProtKB/Swiss-Prot
    A8MSH3, Q9BYQ9
    Related
    ENSP00000328444.4, ENST00000333822.5
    Conserved Domains (2) summary
    pfam01500
    Location:42184
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:59103
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    41096981..41098142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791801.1 Reference GRCh38.p14 PATCHES

    Range
    46784..47945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    246639..247812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    41961756..41962929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)