Tmem135 transmembrane protein 135 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem135provided by MGI
Official Full Name: transmembrane protein 135provided by MGI
Primary source: MGI:MGI:1920009
See related: Ensembl:ENSMUSG00000039428 AllianceGenome:MGI:1920009
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PMP52; 2810439K08Rik
Summary: Involved in regulation of mitochondrial fission. Acts upstream of or within several processes, including regulation of oxidative phosphorylation; response to food; and retinal pigment epithelium development. Located in lipid droplet; mitochondrion; and peroxisome. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 32.4), subcutaneous fat pad adult (RPKM 19.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 49.32 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (88789230..89053911, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (89140022..89404703, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics.
Title: TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics.
TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis.
Title: TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis.
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
Title: Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.
Title: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.
Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice.
Title: Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice.
Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene.
Title: Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene.
The authors observed localization of TMEM135 on mitochondria, and imbalance of mitochondrial fission and fusion in mutant Tmem135 as well as Tmem135 overexpressing cells, indicating that TMEM135 is involved in the regulation of mitochondrial dynamics.
Title: Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.
TMEM135 integrates biological processes involving fat metabolism and energy expenditure in both the worm (invertebrates) and in mammalian organisms
Title: Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of lipid storage	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to food	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to food	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 135

Names: peroxisomal membrane protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360745.1 → NP_001347674.1 transmembrane protein 135 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC116659, AC122386, AC123844

Conserved Domains (1) summary

pfam02466
Location:160 → 212

Tim17; Tim17/Tim22/Tim23/Pmp24 family
NM_001360746.1 → NP_001347675.1 transmembrane protein 135 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' end and lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC116326, AC116659, AC122386, AC123844

Conserved Domains (1) summary

pfam02466
Location:160 → 212

Tim17; Tim17/Tim22/Tim23/Pmp24 family
NM_028343.5 → NP_082619.3 transmembrane protein 135 isoform a

See identical proteins and their annotated locations for NP_082619.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AC116659, AC122386, AK013269

Consensus CDS

CCDS21440.1

UniProtKB/Swiss-Prot

Q8BSY5, Q8CCZ6, Q8CE78, Q9CYV5

Related

ENSMUSP00000042783.4, ENSMUST00000041968.11

Conserved Domains (2) summary

pfam02466
Location:249 → 338

Tim17; Tim17/Tim22/Tim23/Pmp24 family

pfam15982
Location:9 → 142

TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

88789230..89053911 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241911.2 → XP_011240213.1 transmembrane protein 135 isoform X2

Conserved Domains (2) summary

pfam02466
Location:280 → 332

Tim17; Tim17/Tim22/Tim23/Pmp24 family

pfam15982
Location:29 → 123

TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
XM_036153464.1 → XP_036009357.1 transmembrane protein 135 isoform X3

Conserved Domains (1) summary

pfam02466
Location:171 → 223

Tim17; Tim17/Tim22/Tim23/Pmp24 family
XM_030243017.2 → XP_030098877.1 transmembrane protein 135 isoform X3

Conserved Domains (1) summary

pfam02466
Location:171 → 223

Tim17; Tim17/Tim22/Tim23/Pmp24 family
XM_036153466.1 → XP_036009359.1 transmembrane protein 135 isoform X5

Conserved Domains (1) summary

pfam02466
Location:160 → 212

Tim17; Tim17/Tim22/Tim23/Pmp24 family
XM_036153465.1 → XP_036009358.1 transmembrane protein 135 isoform X4

Conserved Domains (1) summary

pfam02466
Location:164 → 216

Tim17; Tim17/Tim22/Tim23/Pmp24 family
XM_030243016.2 → XP_030098876.1 transmembrane protein 135 isoform X1

Conserved Domains (2) summary

pfam02466
Location:384 → 436

Tim17; Tim17/Tim22/Tim23/Pmp24 family

pfam15982
Location:130 → 227

TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
XM_030243018.2 → XP_030098878.1 transmembrane protein 135 isoform X6

Conserved Domains (1) summary

pfam15982
Location:130 → 227

TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135