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Tmem135 transmembrane protein 135 [ Mus musculus (house mouse) ]

Gene ID: 72759, updated on 14-May-2024

Summary

Official Symbol
Tmem135provided by MGI
Official Full Name
transmembrane protein 135provided by MGI
Primary source
MGI:MGI:1920009
See related
Ensembl:ENSMUSG00000039428 AllianceGenome:MGI:1920009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PMP52; 2810439K08Rik
Summary
Involved in regulation of mitochondrial fission. Acts upstream of or within response to cold and response to food. Located in lipid droplet; mitochondrion; and peroxisome. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 32.4), subcutaneous fat pad adult (RPKM 19.0) and 27 other tissues See more
Orthologs
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Genomic context

See Tmem135 in Genome Data Viewer
Location:
7 D3; 7 49.32 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (88789230..89053911, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89140022..89404703, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19485 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 6240 Neighboring gene STARR-seq mESC enhancer starr_19487 Neighboring gene STARR-positive B cell enhancer ABC_E11359 Neighboring gene STARR-positive B cell enhancer ABC_E10449 Neighboring gene STARR-seq mESC enhancer starr_19488 Neighboring gene STARR-positive B cell enhancer ABC_E4946 Neighboring gene STARR-seq mESC enhancer starr_19489 Neighboring gene STARR-seq mESC enhancer starr_19490 Neighboring gene expressed sequence AI314278 Neighboring gene frizzled class receptor 4 Neighboring gene serine protease 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transmembrane protein 135
Names
peroxisomal membrane protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360745.1NP_001347674.1  transmembrane protein 135 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC116659, AC122386, AC123844
    Conserved Domains (1) summary
    pfam02466
    Location:160212
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  2. NM_001360746.1NP_001347675.1  transmembrane protein 135 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' end and lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC116326, AC116659, AC122386, AC123844
    Conserved Domains (1) summary
    pfam02466
    Location:160212
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  3. NM_028343.5NP_082619.3  transmembrane protein 135 isoform a

    See identical proteins and their annotated locations for NP_082619.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC116659, AC122386, AK013269
    Consensus CDS
    CCDS21440.1
    UniProtKB/Swiss-Prot
    Q8BSY5, Q8CCZ6, Q8CE78, Q9CYV5
    Related
    ENSMUSP00000042783.4, ENSMUST00000041968.11
    Conserved Domains (2) summary
    pfam02466
    Location:249338
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
    pfam15982
    Location:9142
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    88789230..89053911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241911.2XP_011240213.1  transmembrane protein 135 isoform X2

    Conserved Domains (2) summary
    pfam02466
    Location:280332
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
    pfam15982
    Location:29123
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
  2. XM_036153464.1XP_036009357.1  transmembrane protein 135 isoform X3

    Conserved Domains (1) summary
    pfam02466
    Location:171223
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  3. XM_030243017.2XP_030098877.1  transmembrane protein 135 isoform X3

    Conserved Domains (1) summary
    pfam02466
    Location:171223
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  4. XM_036153466.1XP_036009359.1  transmembrane protein 135 isoform X5

    Conserved Domains (1) summary
    pfam02466
    Location:160212
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  5. XM_036153465.1XP_036009358.1  transmembrane protein 135 isoform X4

    Conserved Domains (1) summary
    pfam02466
    Location:164216
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
  6. XM_030243016.2XP_030098876.1  transmembrane protein 135 isoform X1

    Conserved Domains (2) summary
    pfam02466
    Location:384436
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
    pfam15982
    Location:130227
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
  7. XM_030243018.2XP_030098878.1  transmembrane protein 135 isoform X6

    Conserved Domains (1) summary
    pfam15982
    Location:130227
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135