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TSPY1 testis specific protein Y-linked 1 [ Homo sapiens (human) ]

Gene ID: 7258, updated on 11-Jun-2021

Summary

Official Symbol
TSPY1provided by HGNC
Official Full Name
testis specific protein Y-linked 1provided by HGNC
Primary source
HGNC:HGNC:12381
See related
Ensembl:ENSG00000258992 MIM:480100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT78; TSPY; DYS14; pJA923
Summary
The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Restricted expression toward testis (RPKM 33.8) See more
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Genomic context

See TSPY1 in Genome Data Viewer
Location:
Yp11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (9466955..9469756)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9304564..9307358)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein Y-linked 3 Neighboring gene family with sequence similarity 197 Y-linked member 5 Neighboring gene family with sequence similarity 197 Y-linked member 4 Neighboring gene testis specific protein Y-linked 9, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in sex differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-specific Y-encoded protein 1
Names
cancer/testis antigen 78
testis specific protein, Y-linked

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027958.1 RefSeqGene

    Range
    5001..7795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197242.2NP_001184171.1  testis-specific Y-encoded protein 1 isoform TSPY-L

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice compared to variant 1, which results in a frameshift. The resulting isoform (TSPY-L) has a shorter and distinct C-terminus compared to isoform TSPY1-S.
    Source sequence(s)
    AC006156
    Consensus CDS
    CCDS76071.1
    UniProtKB/Swiss-Prot
    Q01534
    Related
    ENSP00000389324.3, ENST00000423647.6
    Conserved Domains (1) summary
    cl08298
    Location:103273
    NAP; Nucleosome assembly protein (NAP)
  2. NM_001320964.2NP_001307893.1  testis-specific Y-encoded protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AI002165, BC121113
    UniProtKB/TrEMBL
    A4FUW6
    Conserved Domains (1) summary
    cl08298
    Location:39201
    NAP; Nucleosome assembly protein (NAP)
  3. NM_003308.4NP_003299.2  testis-specific Y-encoded protein 1 isoform TSPY-S

    See identical proteins and their annotated locations for NP_003299.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (TSPY-S).
    Source sequence(s)
    AC006156
    Consensus CDS
    CCDS48205.1
    UniProtKB/Swiss-Prot
    Q01534
    Related
    ENSP00000403304.1, ENST00000451548.6
    Conserved Domains (1) summary
    cl08298
    Location:126288
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    9466955..9469756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017030064.1XP_016885553.1  testis-specific Y-encoded protein 1 isoform X1

RNA

  1. XR_001756005.1 RNA Sequence

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