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Slc43a1 solute carrier family 43, member 1 [ Mus musculus (house mouse) ]

Gene ID: 72401, updated on 2-Nov-2024

Summary

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Official Symbol
Slc43a1provided by MGI
Official Full Name
solute carrier family 43, member 1provided by MGI
Primary source
MGI:MGI:1931352
See related
Ensembl:ENSMUSG00000027075 AllianceGenome:MGI:1931352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lat3; PB39; Pov1; R00504; 2610016F07Rik
Summary
Enables L-isoleucine transmembrane transporter activity; L-leucine transmembrane transporter activity; and L-valine transmembrane transporter activity. Involved in L-leucine transport; L-valine transmembrane transport; and isoleucine transport. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; blood island; liver; neural ectoderm; and nose. Orthologous to human SLC43A1 (solute carrier family 43 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14.5 (RPKM 49.5), liver E14 (RPKM 42.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Slc43a1 in Genome Data Viewer
Location:
2 D; 2 49.45 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84669196..84693930)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84838855..84863586)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05011 Neighboring gene smoothelin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E2628 Neighboring gene RIKEN cDNA D930003E18 gene Neighboring gene translocase of inner mitochondrial membrane 10 Neighboring gene reticulon 4 receptor-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E8789 Neighboring gene STARR-positive B cell enhancer ABC_E11144 Neighboring gene STARR-positive B cell enhancer ABC_E2629 Neighboring gene solute carrier family 43, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein characterization of NA+-independent system L amino acid transporter 3 in mice: a potential role in supply of branched-chain amino acids under nutrient starvation. Fukuhara D, et al. Am J Pathol, 2007 Mar. PMID 17322374, Free PMC Article
  2. cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer. Cole KA, et al. Genomics, 1998 Jul 15. PMID 9722952
  3. Identification of LAT4, a novel amino acid transporter with system L activity. Bodoy S, et al. J Biol Chem, 2005 Mar 25. PMID 15659399
  4. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Chung J, et al. Sci Signal, 2015 Apr 14. PMID 25872869, Free PMC Article
  5. Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Huang S, et al. Nat Commun, 2024 Aug 15. PMID 39147774, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-isoleucine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-isoleucine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-leucine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-leucine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-valine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-valine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-valine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-valine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in isoleucine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isoleucine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutral amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in podocyte foot ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large neutral amino acids transporter small subunit 3
Names
L-type amino acid transporter 3
prostate cancer overexpressed gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081349.2 → NP_001074818.2  large neutral amino acids transporter small subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_001074818.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK046758, BX522717, CJ307166
    Consensus CDS
    CCDS50624.1
    UniProtKB/TrEMBL
    G3X8X3
    Related
    ENSMUSP00000028469.8, ENSMUST00000028469.14
    Conserved Domains (1) summary
    cd06174
    Location:118 → 262
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. NM_001083809.1 → NP_001077278.1  large neutral amino acids transporter small subunit 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a distinct ATG and an isoform (3) with a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK031215
    Consensus CDS
    CCDS38162.1
    UniProtKB/TrEMBL
    A2ATS4
    Related
    ENSMUSP00000107252.2, ENSMUST00000111625.2
    Conserved Domains (1) summary
    cd06174
    Location:101 → 245
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  3. NM_024497.1 → NP_078773.1  large neutral amino acids transporter small subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_078773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC053747, CJ186653, CJ307166
    Consensus CDS
    CCDS38163.1
    UniProtKB/Swiss-Prot
    A2ATS3, Q8BSM7, Q9D0H7
    Related
    ENSMUSP00000107251.2, ENSMUST00000111624.8
    Conserved Domains (1) summary
    cl28910
    Location:75 → 241
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84669196..84693930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500231.5 → XP_006500294.1  large neutral amino acids transporter small subunit 3 isoform X3

    Conserved Domains (1) summary
    cl28910
    Location:51 → 217
    MFS; Major Facilitator Superfamily

  2. XM_036162592.1 → XP_036018485.1  large neutral amino acids transporter small subunit 3 isoform X2

    Conserved Domains (1) summary
    cd06174
    Location:202 → 368
    MFS; Major Facilitator Superfamily

  3. XM_036162593.1 → XP_036018486.1  large neutral amino acids transporter small subunit 3 isoform X4

  4. XM_036162591.1 → XP_036018484.1  large neutral amino acids transporter small subunit 3 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:202 → 368
    MFS; Major Facilitator Superfamily

  5. XM_036162594.1 → XP_036018487.1  large neutral amino acids transporter small subunit 3 isoform X5

  6. XM_036162595.1 → XP_036018488.1  large neutral amino acids transporter small subunit 3 isoform X7

    Conserved Domains (1) summary
    cl28910
    Location:197 → 307
    MFS; Major Facilitator Superfamily

  7. XM_006500230.4 → XP_006500293.1  large neutral amino acids transporter small subunit 3 isoform X6

    See identical proteins and their annotated locations for XP_006500293.1

    UniProtKB/Swiss-Prot
    A2ATS3, Q8BSM7, Q9D0H7
    Related
    ENSMUSP00000112642.2, ENSMUST00000121114.8
    Conserved Domains (1) summary
    cl28910
    Location:75 → 241
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSM7.1 GenPept UniProtKB/Swiss-Prot:Q8BSM7

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