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Cdkn3 cyclin-dependent kinase inhibitor 3 [ Mus musculus (house mouse) ]

Gene ID: 72391, updated on 12-Aug-2018
Official Symbol
Cdkn3provided by MGI
Official Full Name
cyclin-dependent kinase inhibitor 3provided by MGI
Primary source
MGI:MGI:1919641
See related
Ensembl:ENSMUSG00000037628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAP; 2410006H10Rik
Expression
Biased expression in testis adult (RPKM 55.4), liver E14 (RPKM 19.2) and 6 other tissues See more
Orthologs
See Cdkn3 in Genome Data Viewer
Location:
14; 14 C1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (46760465..46771530)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (47380216..47391200)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933425B07 gene Neighboring gene predicted gene, 41146 Neighboring gene RIKEN cDNA D330046F09 gene Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene glia maturation factor, beta

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cyclin-dependent kinase inhibitor 3
Names
CDK2-associated dual-specificity phosphatase
cdkn3
kinase-associated phosphatase
NP_082498.1
XP_006519655.1
XP_006519656.1
XP_006519657.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360041.1NP_001346970.1  cyclin-dependent kinase inhibitor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA218046, AA510251, BY084534
    Conserved Domains (1) summary
    pfam05706
    Location:1168
    CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)
  2. NM_028222.2NP_082498.1  cyclin-dependent kinase inhibitor 3 isoform 2

    See identical proteins and their annotated locations for NP_082498.1

    Status: VALIDATED

    Source sequence(s)
    AA218046, BC049694, BY084534
    Consensus CDS
    CCDS49466.1
    UniProtKB/Swiss-Prot
    Q810P3
    Related
    ENSMUSP00000070575.4, ENSMUST00000067426.5
    Conserved Domains (1) summary
    pfam05706
    Location:1167
    CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    46760465..46771530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519594.3XP_006519657.1  cyclin-dependent kinase inhibitor 3 isoform X2

    See identical proteins and their annotated locations for XP_006519657.1

    Conserved Domains (2) summary
    COG2453
    Location:86178
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cl21483
    Location:17154
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_006519593.3XP_006519656.1  cyclin-dependent kinase inhibitor 3 isoform X2

    See identical proteins and their annotated locations for XP_006519656.1

    Conserved Domains (2) summary
    COG2453
    Location:86178
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cl21483
    Location:17154
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_006519592.3XP_006519655.1  cyclin-dependent kinase inhibitor 3 isoform X1

    Conserved Domains (1) summary
    pfam05706
    Location:1168
    CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)
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