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Cdkn3 cyclin dependent kinase inhibitor 3 [ Mus musculus (house mouse) ]

Gene ID: 72391, updated on 1-Mar-2024

Summary

Official Symbol
Cdkn3provided by MGI
Official Full Name
cyclin dependent kinase inhibitor 3provided by MGI
Primary source
MGI:MGI:1919641
See related
Ensembl:ENSMUSG00000037628 AllianceGenome:MGI:1919641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAP; 2410006H10Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to act upstream of or within cellular response to DNA damage stimulus and regulation of cell cycle. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in axial skeleton; cerebral cortex; cranium; hindlimb long bone; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 55.4), liver E14 (RPKM 19.2) and 6 other tissues See more
Orthologs
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Genomic context

See Cdkn3 in Genome Data Viewer
Location:
14 24.28 cM; 14 C1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (46997912..47008987)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46760461..46771530)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933425B07 gene Neighboring gene predicted gene, 41146 Neighboring gene RIKEN cDNA D330046F09 gene Neighboring gene STARR-seq mESC enhancer starr_36562 Neighboring gene STARR-seq mESC enhancer starr_36563 Neighboring gene STARR-positive B cell enhancer ABC_E752 Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7306 Neighboring gene glia maturation factor, beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase inhibitor 3
Names
CDK2-associated dual-specificity phosphatase
kinase-associated phosphatase
NP_001346970.1
NP_082498.1
XP_006519656.1
XP_006519657.1
XP_030103904.1
XP_036014748.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360041.1NP_001346970.1  cyclin-dependent kinase inhibitor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA218046, AA510251, BY084534
    Related
    ENSMUST00000226621.2
    Conserved Domains (1) summary
    pfam05706
    Location:1168
    CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)
  2. NM_028222.2NP_082498.1  cyclin-dependent kinase inhibitor 3 isoform 2

    See identical proteins and their annotated locations for NP_082498.1

    Status: VALIDATED

    Source sequence(s)
    AA218046, BC049694, BY084534
    Consensus CDS
    CCDS49466.1
    UniProtKB/Swiss-Prot
    Q810P3, Q9CWS3
    Related
    ENSMUSP00000070575.5, ENSMUST00000067426.6
    Conserved Domains (1) summary
    pfam05706
    Location:1167
    CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    46997912..47008987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158855.1XP_036014748.1  cyclin-dependent kinase inhibitor 3 isoform X1

    UniProtKB/TrEMBL
    A0A2I3BPS7
    Related
    ENSMUSP00000154120.2, ENSMUST00000228106.2
    Conserved Domains (1) summary
    cl28904
    Location:1139
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_030248044.1XP_030103904.1  cyclin-dependent kinase inhibitor 3 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:17153
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. XM_006519594.4XP_006519657.1  cyclin-dependent kinase inhibitor 3 isoform X2

    See identical proteins and their annotated locations for XP_006519657.1

    Conserved Domains (1) summary
    cl28904
    Location:17154
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. XM_006519593.3XP_006519656.1  cyclin-dependent kinase inhibitor 3 isoform X2

    See identical proteins and their annotated locations for XP_006519656.1

    Conserved Domains (1) summary
    cl28904
    Location:17154
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily