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2210016L21Rik RIKEN cDNA 2210016L21 gene [ Mus musculus (house mouse) ]

Gene ID: 72357, updated on 30-Apr-2024

Summary

Official Symbol
2210016L21Rikprovided by MGI
Official Full Name
RIKEN cDNA 2210016L21 geneprovided by MGI
Primary source
MGI:MGI:1919607
See related
Ensembl:ENSMUSG00000029559 AllianceGenome:MGI:1919607
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Custos
Summary
Predicted to be involved in Spemann organizer formation and negative regulation of Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in nucleus. Orthologous to human C12orf43 (chromosome 12 open reading frame 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 29.9), cortex adult (RPKM 28.5) and 28 other tissues See more
Orthologs
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Genomic context

See 2210016L21Rik in Genome Data Viewer
Location:
5 F; 5 55.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115080213..115086610)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114942154..114948540)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13822 Neighboring gene 2'-5' oligoadenylate synthetase-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1057 Neighboring gene HNF1 homeobox A Neighboring gene STARR-seq mESC enhancer starr_14093 Neighboring gene HNF1 homeobox A, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_14096 Neighboring gene signal peptide peptidase 3 Neighboring gene STARR-seq mESC enhancer starr_14098 Neighboring gene STARR-seq mESC enhancer starr_14099 Neighboring gene predicted gene, 54336

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Spemann organizer formation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein CUSTOS
Names
uncharacterized protein C12orf43 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028211.1NP_082487.1  protein CUSTOS

    See identical proteins and their annotated locations for NP_082487.1

    Status: PROVISIONAL

    Source sequence(s)
    BC031162
    Consensus CDS
    CCDS19576.1
    UniProtKB/Swiss-Prot
    Q3TX98, Q3UY34, Q8K0K9, Q9CVB7
    UniProtKB/TrEMBL
    A0A0R4J099
    Related
    ENSMUSP00000031538.9, ENSMUST00000031538.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115080213..115086610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165521.1XP_036021414.1  protein CUSTOS isoform X1

    UniProtKB/Swiss-Prot
    Q3TX98, Q3UY34, Q8K0K9, Q9CVB7