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Ttc4 tetratricopeptide repeat domain 4 [ Mus musculus (house mouse) ]

Gene ID: 72354, updated on 30-Apr-2024

Summary

Official Symbol
Ttc4provided by MGI
Official Full Name
tetratricopeptide repeat domain 4provided by MGI
Primary source
MGI:MGI:1919604
See related
Ensembl:ENSMUSG00000025413 AllianceGenome:MGI:1919604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L62; 2810002P21Rik
Summary
Predicted to enable Hsp90 protein binding activity. Predicted to be involved in defense response to virus and innate immune response. Predicted to act upstream of or within immune system process. Located in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; olfactory epithelium; renal cortex; and thymus primordium. Orthologous to human TTC4 (tetratricopeptide repeat domain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 33.7), CNS E18 (RPKM 31.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ttc4 in Genome Data Viewer
Location:
4 C7; 4 49.68 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106514952..106536188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106656806..106679002, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10244 Neighboring gene tetratricopeptide repeat domain 22 Neighboring gene STARR-positive B cell enhancer ABC_E2700 Neighboring gene prolyl-tRNA synthetase (mitochondrial)(putative) Neighboring gene STARR-positive B cell enhancer ABC_E6195 Neighboring gene maestro heat-like repeat family member 7 Neighboring gene family with sequence simliarity 151, member A Neighboring gene acyl-CoA thioesterase 11 Neighboring gene STARR-positive B cell enhancer ABC_E4640

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Hsp90 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 4
Names
TPR repeat protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172073.1NP_001165544.1  tetratricopeptide repeat protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001165544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK005923, AK133931
    UniProtKB/TrEMBL
    Q3UZC4
    Related
    ENSMUST00000142342.8
    Conserved Domains (2) summary
    TIGR00990
    Location:28173
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:3462
    TPR; TPR repeat [structural motif]
  2. NM_028209.2NP_082485.1  tetratricopeptide repeat protein 4 isoform 1

    See identical proteins and their annotated locations for NP_082485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AK005923, AK012652, AK133931, BY060470
    Consensus CDS
    CCDS18424.1
    UniProtKB/Swiss-Prot
    Q8R3H9
    UniProtKB/TrEMBL
    Q3UZC4
    Related
    ENSMUSP00000026480.7, ENSMUST00000026480.13
    Conserved Domains (2) summary
    sd00006
    Location:79107
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:78148
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    106514952..106536188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503408.5XP_006503471.1  tetratricopeptide repeat protein 4 isoform X1

    UniProtKB/TrEMBL
    Q3UZC4
    Conserved Domains (2) summary
    TIGR00990
    Location:73218
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:79107
    TPR; TPR repeat [structural motif]
  2. XM_036164455.1XP_036020348.1  tetratricopeptide repeat protein 4 isoform X3

    Conserved Domains (1) summary
    pfam18972
    Location:71155
    Wheel; Cns1/TTC4 Wheel domain
  3. XM_006503409.5XP_006503472.1  tetratricopeptide repeat protein 4 isoform X2

    UniProtKB/TrEMBL
    Q3UZC4
    Conserved Domains (2) summary
    TIGR00990
    Location:28173
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:3462
    TPR; TPR repeat [structural motif]