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Lrrc8e leucine rich repeat containing 8 family, member E [ Mus musculus (house mouse) ]

Gene ID: 72267, updated on 12-May-2024

Summary

Official Symbol
Lrrc8eprovided by MGI
Official Full Name
leucine rich repeat containing 8 family, member Eprovided by MGI
Primary source
MGI:MGI:1919517
See related
Ensembl:ENSMUSG00000046589 AllianceGenome:MGI:1919517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810049O03Rik
Summary
Predicted to contribute to volume-sensitive anion channel activity. Involved in cyclic-GMP-AMP transmembrane import across plasma membrane. Predicted to be located in cytoplasm and plasma membrane. Predicted to be integral component of endoplasmic reticulum membrane; integral component of lysosomal membrane; and integral component of plasma membrane. Predicted to be part of ion channel complex. Orthologous to human LRRC8E (leucine rich repeat containing 8 VRAC subunit E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 4.6), bladder adult (RPKM 3.6) and 8 other tissues See more
Orthologs
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Genomic context

See Lrrc8e in Genome Data Viewer
Location:
8 A1.1; 8 1.99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4274269..4287470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4224268..4237470)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932443L11 gene Neighboring gene ecotropic viral integration site 5 like Neighboring gene STARR-seq mESC enhancer starr_20610 Neighboring gene proline rich 36 Neighboring gene mitogen-activated protein kinase kinase 7 Neighboring gene transforming growth factor, beta receptor III-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC91131

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to volume-sensitive anion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables volume-sensitive anion channel activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of monoatomic ion channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
volume-regulated anion channel subunit LRRC8E
Names
leucine-rich repeat-containing protein 8E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028175.2NP_082451.2  volume-regulated anion channel subunit LRRC8E

    See identical proteins and their annotated locations for NP_082451.2

    Status: VALIDATED

    Source sequence(s)
    AC123029, BC080783
    Consensus CDS
    CCDS22079.1
    UniProtKB/Swiss-Prot
    E9QNV5, Q66JT1
    Related
    ENSMUSP00000052055.7, ENSMUST00000053035.7
    Conserved Domains (4) summary
    PLN00113
    Location:412756
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:606771
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:559582
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1330
    Pannexin_like; Pannexin-like TM region of LRRC8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    4274269..4287470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242086.4XP_011240388.1  volume-regulated anion channel subunit LRRC8E isoform X1

    See identical proteins and their annotated locations for XP_011240388.1

    UniProtKB/Swiss-Prot
    E9QNV5, Q66JT1
    Conserved Domains (4) summary
    PLN00113
    Location:412756
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:606771
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:559582
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1330
    Pannexin_like; Pannexin-like TM region of LRRC8
  2. XM_006508908.3XP_006508971.1  volume-regulated anion channel subunit LRRC8E isoform X2

    Conserved Domains (3) summary
    PLN00113
    Location:37381
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:231396
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:184207
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_006508907.3XP_006508970.1  volume-regulated anion channel subunit LRRC8E isoform X1

    See identical proteins and their annotated locations for XP_006508970.1

    UniProtKB/Swiss-Prot
    E9QNV5, Q66JT1
    Conserved Domains (4) summary
    PLN00113
    Location:412756
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:606771
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:559582
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1330
    Pannexin_like; Pannexin-like TM region of LRRC8
  4. XM_006508906.4XP_006508969.1  volume-regulated anion channel subunit LRRC8E isoform X1

    See identical proteins and their annotated locations for XP_006508969.1

    UniProtKB/Swiss-Prot
    E9QNV5, Q66JT1
    Conserved Domains (4) summary
    PLN00113
    Location:412756
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:606771
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:559582
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1330
    Pannexin_like; Pannexin-like TM region of LRRC8