TRPC5 transient receptor potential cation channel subfamily C member 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRPC5provided by HGNC
Official Full Name: transient receptor potential cation channel subfamily C member 5provided by HGNC
Primary source: HGNC:HGNC:12337
See related: Ensembl:ENSG00000072315 MIM:300334; AllianceGenome:HGNC:12337
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRP5; PPP1R159
Summary: This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: Xq23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (111768011..112082776, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (110216352..110531119, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (111011239..111326004, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cellular context determines primary characteristics of human TRPC5 as a cold-activated channel.
Title: Cellular context determines primary characteristics of human TRPC5 as a cold-activated channel.
Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Title: Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.
Title: Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.
Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.
Title: Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.
TRPC5 in cardiovascular diseases.
Title: TRPC5 in cardiovascular diseases.
Involvement of TRPC5 channels, inwardly rectifying K(+) channels, PLCbeta and PIP2 in vasopressin-mediated excitation of medial central amygdala neurons.
Title: Involvement of TRPC5 channels, inwardly rectifying K(+) channels, PLCβ and PIP(2) in vasopressin-mediated excitation of medial central amygdala neurons.
PIP2 regulation of TRPC5 channel activation and desensitization.
Title: PIP(2) regulation of TRPC5 channel activation and desensitization.
Regulation of TRPC5 currents by intracellular ATP: Single channel studies.
Title: Regulation of TRPC5 currents by intracellular ATP: Single channel studies.
Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.
Title: Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.
Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.
Title: Differential PI(4,5)P(2) sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide and candidate gene association study of cigarette smoking behaviors. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXS7458 (e-PCR)
- UniSTS:99073

AL008924 (e-PCR)
- UniSTS:76806

DXS8201 (e-PCR)
- UniSTS:49167

DXS1280 (e-PCR)
- UniSTS:1312

DXS7300 (e-PCR)
- UniSTS:29738

DXS1059 (e-PCR)
- UniSTS:9773

RH47107 (e-PCR)
- UniSTS:24673

DXS7354 (e-PCR)
- UniSTS:36458

RH103574 (e-PCR)
- UniSTS:97899

AL021628 (e-PCR)
- UniSTS:8055

DXS1059 (e-PCR)
- UniSTS:30328

RH118893 (e-PCR)
- UniSTS:138884

DXS8203 (e-PCR)
- UniSTS:78986

AL035134 (e-PCR)
- UniSTS:94644

L77248 (e-PCR)
- UniSTS:48328

DXS7344 (e-PCR)
- UniSTS:58834

DXS1352 (e-PCR)
- UniSTS:99041

DXS8204 (e-PCR)
- UniSTS:62965

DXS8110 (e-PCR), detects polymorphism
- UniSTS:13815

AL031569 (e-PCR)
- UniSTS:30968

Homology

Homologs of the TRPC5 gene: The TRPC5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 333 organisms have orthologs with human gene TRPC5
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actinin binding	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	TAS Traceable Author Statement more info
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in calcium ion transmembrane transport	TAS Traceable Author Statement more info
involved_in calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine exposure on apoptotic cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of membrane hyperpolarization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: short transient receptor potential channel 5

Names: TRP-5; hTRP5; protein phosphatase 1, regulatory subunit 159; transient receptor potential channel 5; transient receptor protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021215.2 RefSeqGene

Range

5001..313463

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_012471.3 → NP_036603.1 short transient receptor potential channel 5

See identical proteins and their annotated locations for NP_036603.1

Status: REVIEWED

Source sequence(s)

AF054568, AL031388, AL049563

Consensus CDS

CCDS14561.1

UniProtKB/Swiss-Prot

Q9UL62, Q9Y514

Related

ENSP00000262839.2, ENST00000262839.3

Conserved Domains (2) summary

TIGR00870
Location:17 → 756

trp; transient-receptor-potential calcium channel protein

sd00045
Location:35 → 67

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

111768011..112082776 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017029774.2 → XP_016885263.1 short transient receptor potential channel 5 isoform X1

UniProtKB/Swiss-Prot

Q9UL62, Q9Y514

Conserved Domains (2) summary

TIGR00870
Location:17 → 756

trp; transient-receptor-potential calcium channel protein

sd00045
Location:35 → 67

ANK; ANK repeat [structural motif]
XM_047442413.1 → XP_047298369.1 short transient receptor potential channel 5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

110216352..110531119 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054327673.1 → XP_054183648.1 short transient receptor potential channel 5 isoform X1

UniProtKB/Swiss-Prot

Q9Y514
XM_054327674.1 → XP_054183649.1 short transient receptor potential channel 5 isoform X2