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TRPC5 transient receptor potential cation channel subfamily C member 5 [ Homo sapiens (human) ]

Gene ID: 7224, updated on 8-Jul-2021

Summary

Official Symbol
TRPC5provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 5provided by HGNC
Primary source
HGNC:HGNC:12337
See related
Ensembl:ENSG00000072315 MIM:300334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP5; PPP1R159
Summary
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TRPC5 in Genome Data Viewer
Location:
Xq23
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (111768011..112082943, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (111011239..111326004, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 512 Neighboring gene ALG13 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene TRPC5 opposite strand Neighboring gene retrotransposon Gag like 4 Neighboring gene divergent-paired related homeobox pseudogene 7 Neighboring gene CCDC121 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide and candidate gene association study of cigarette smoking behaviors.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actinin binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel activity TAS
Traceable Author Statement
more info
 
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
 
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in manganese ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylserine exposure on apoptotic cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane hyperpolarization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
short transient receptor potential channel 5
Names
TRP-5
hTRP5
protein phosphatase 1, regulatory subunit 159
transient receptor potential channel 5
transient receptor protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021215.2 RefSeqGene

    Range
    5001..313463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012471.3NP_036603.1  short transient receptor potential channel 5

    See identical proteins and their annotated locations for NP_036603.1

    Status: REVIEWED

    Source sequence(s)
    AF054568, AL031388, AL049563
    Consensus CDS
    CCDS14561.1
    UniProtKB/Swiss-Prot
    Q9UL62
    Related
    ENSP00000262839.2, ENST00000262839.3
    Conserved Domains (2) summary
    TIGR00870
    Location:17756
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:3567
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    111768011..112082943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029774.1XP_016885263.1  short transient receptor potential channel 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9UL62
    Conserved Domains (2) summary
    TIGR00870
    Location:17756
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:3567
    ANK; ANK repeat [structural motif]
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