U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pgm1 phosphoglucomutase 1 [ Mus musculus (house mouse) ]

Gene ID: 72157, updated on 1-Mar-2024

Summary

Official Symbol
Pgm1provided by MGI
Official Full Name
phosphoglucomutase 1provided by MGI
Primary source
MGI:MGI:97565
See related
Ensembl:ENSMUSG00000025791 AllianceGenome:MGI:97565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgm2; Pgm-2; Pgm1a; 2610020G18Rik
Summary
Enables phosphoglucomutase activity. Acts upstream of or within glucose metabolic process. Predicted to be located in Z disc. Predicted to be active in cytosol. Is expressed in embryo and heart. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation It; endometrial cancer; and teratoma. Orthologous to human PGM1 (phosphoglucomutase 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: The name of this locus, Pgm1, was recently updated by Mouse Genomic Informatics to be consistent with mammalian orthologs identified as Pgm1. Note that this gene is frequently referred to as Pgm2 in the literature. [02 Oct 2019]
Expression
Ubiquitous expression in liver E18 (RPKM 86.8), mammary gland adult (RPKM 70.6) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pgm1 in Genome Data Viewer
Location:
4 C6; 4 45.71 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (99786648..99844491)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (99929451..99987294)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene integrin beta 3 binding protein (beta3-endonexin) Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:99495752-99496005 Neighboring gene EF-hand calcium binding domain 7 Neighboring gene STARR-positive B cell enhancer ABC_E6193 Neighboring gene predicted gene, 26425 Neighboring gene STARR-seq mESC enhancer starr_10877 Neighboring gene predicted gene, 35701 Neighboring gene predicted gene 12701 Neighboring gene receptor tyrosine kinase-like orphan receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoglucomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoglucomutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoglucomutase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoglucomutase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in organic substance metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphoglucomutase-1
Names
glucose phosphomutase 1
phosphoglucomutase 2
NP_082408.3
XP_036020346.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028132.3NP_082408.3  phosphoglucomutase-1

    See identical proteins and their annotated locations for NP_082408.3

    Status: VALIDATED

    Source sequence(s)
    AK147982, AK152923
    Consensus CDS
    CCDS18388.1
    UniProtKB/Swiss-Prot
    Q3UGE3, Q922D6, Q9D0F9
    UniProtKB/TrEMBL
    Q5RJV4
    Related
    ENSMUSP00000061227.10, ENSMUST00000058351.16
    Conserved Domains (1) summary
    cd03085
    Location:5562
    PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    99786648..99844491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164453.1XP_036020346.1  phosphoglucomutase-1 isoform X1

    UniProtKB/TrEMBL
    A2CEK3, Q5RJV4
    Related
    ENSMUSP00000099844.5, ENSMUST00000102783.5
    Conserved Domains (1) summary
    cd03085
    Location:24580
    PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...