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Rfc5 replication factor C (activator 1) 5 [ Mus musculus (house mouse) ]

Gene ID: 72151, updated on 2-Nov-2024

Summary

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Official Symbol
Rfc5provided by MGI
Official Full Name
replication factor C (activator 1) 5provided by MGI
Primary source
MGI:MGI:1919401
See related
Ensembl:ENSMUSG00000029363 AllianceGenome:MGI:1919401
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
36kDa; Recc5; 36.5kDa; 2610020K06Rik; 2610209F07Rik
Summary
Enables enzyme binding activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC5 (replication factor C subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 17.2), liver E14.5 (RPKM 16.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rfc5 in Genome Data Viewer
Location:
5 F; 5 56.88 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117517210..117527088, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117379145..117389023, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14176 Neighboring gene predicted gene, 42012 Neighboring gene WD repeat and SOCS box-containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:117838823-117838932 Neighboring gene STARR-positive B cell enhancer ABC_E6370 Neighboring gene STARR-seq mESC enhancer starr_14179 Neighboring gene predicted gene 15728 Neighboring gene STARR-seq mESC enhancer starr_14180 Neighboring gene STARR-seq mESC enhancer starr_14181 Neighboring gene STARR-seq mESC enhancer starr_14183 Neighboring gene predicted gene, 52829

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cDNAs encoding the large subunit of human replication factor C. Bunz F, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248204, Free PMC Article
  2. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439
  3. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
  4. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
  5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC113787

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to DNA clamp loader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
part_of Ctf18 RFC-like complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
replication factor C subunit 5
Names
A1 36 kDa subunit
RF-C 36 kDa subunit
RFC36
activator 1 36 kDa subunit
activator 1 subunit 5
replication factor C 36 kDa subunit
replication factor C 5
replication factor C, 36 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028128.1 → NP_082404.1  replication factor C subunit 5

    See identical proteins and their annotated locations for NP_082404.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089001
    Consensus CDS
    CCDS39235.1
    UniProtKB/Swiss-Prot
    Q9D0F6
    UniProtKB/TrEMBL
    Q3UDK3, Q5HZI8
    Related
    ENSMUSP00000083652.7, ENSMUST00000086461.13
    Conserved Domains (4) summary
    cd00009
    Location:34 → 175
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    PRK00440
    Location:17 → 328
    rfc; replication factor C small subunit; Reviewed
    pfam08542
    Location:257 → 326
    Rep_fac_C; Replication factor C C-terminal domain
    pfam16193
    Location:191 → 219
    AAA_assoc_2; AAA C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    117517210..117527088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0F6.1 GenPept UniProtKB/Swiss-Prot:Q9D0F6

Gene LinkOut

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